Simulation scenario 4, CR phase

Setting description

Hormone therapies more effective in the TP53- & AR- biomarker signature

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.084, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 11.7, median = 8.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.33, hr = 0.74	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.087, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 11.3, median = 8.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.28, hr = 0.77	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.093, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 10.5, median = 7.6	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1.2, hr = 0.83	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.042, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 23.4, median = 16.9	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 2.67, hr = 0.36	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 29 2 1 0 TP53- & AR- 414 6 3 2 TP53+ 6 0 3 2 DRD+ 5 0 1 1 TEfus+ 8 3 2 3

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.058 0.004 0.002 0.000 TP53- & AR- 0.828 0.012 0.006 0.004 TP53+ 0.012 0.000 0.006 0.004 DRD+ 0.010 0.000 0.002 0.002 TEfus+ 0.016 0.006 0.004 0.006

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 4 4 2 1 TP53- & AR- 1 386 405 401 TP53+ 31 39 26 26 DRD+ 2 39 58 36 TEfus+ 6 61 43 40

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.008 0.008 0.004 0.002 TP53- & AR- 0.002 0.772 0.810 0.802 TP53+ 0.062 0.078 0.052 0.052 DRD+ 0.004 0.078 0.116 0.072 TEfus+ 0.012 0.122 0.086 0.080

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 50 18 19 25 TP53+ 4 11 10 7 DRD+ 0 0 0 0 TEfus+ 1 0 0 0

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.100 0.036 0.038 0.050 TP53+ 0.008 0.022 0.020 0.014 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.002 0.000 0.000 0.000

Errors & power

The overall error was 0.09.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.044             0.022             0.020             0.016 

The overall power was 0.828.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.828             0.000             0.000             0.000 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	29	2	1	0
	futility	0	4	4	2	1
	max_n	0	0	0	0	0
	n	411 (348, 451)	159 (104, 256)	174 (126, 248)	163 (118, 247)	173 (124, 251)
	n_unique	379 (321, 417)	146 (94, 242)	160 (115, 228)	150 (108, 230)	159 (113, 234)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	5 (4, 8)	11 (6, 24)	19 (9, 27)	22 (22, 22)
	post_p	NA (NA, NA)	0.97 (0.67, 1)	0.04 (0, 0.28)	0.04 (0, 0.3)	0.05 (0, 0.32)
	rate	0.094 (0.087, 0.101)	0.077 (0.061, 0.09)	0.114 (0.102, 0.126)	0.114 (0.102, 0.126)	0.112 (0.101, 0.126)
TP53- & AR-	graduation	0	414	6	3	2
	futility	0	1	386	405	401
	max_n	0	50	18	19	25
	n	175 (109, 205)	35 (25, 151)	43 (25, 126)	41 (26, 130)	46 (26, 137)
	n_unique	163 (100, 191)	33 (24, 141)	40 (23, 119)	38 (24, 119)	43 (24, 128)
	time_trial	36 (36, 36)	11 (7, 36)	24 (14, 36)	23 (13, 36)	23 (14, 36)
	time_stop	NA (NA, NA)	9 (7, 22)	21 (13, 33)	20 (13, 32)	20 (13, 32)
	post_p	NA (NA, NA)	1 (0.97, 1)	0.02 (0, 0.14)	0.02 (0, 0.12)	0.02 (0, 0.13)
	rate	0.075 (0.066, 0.084)	0.042 (0.032, 0.051)	0.115 (0.096, 0.144)	0.118 (0.097, 0.147)	0.114 (0.096, 0.145)
TP53+	graduation	0	6	0	3	2
	futility	0	31	39	26	26
	max_n	0	4	11	10	7
	n	181 (159, 204)	83 (34, 120)	88 (52, 125)	85 (57, 123)	87 (55, 125)
	n_unique	166 (145, 188)	76 (33, 111)	82 (48, 116)	79 (51, 114)	81 (49, 115)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	15 (10, 30)	19 (13, 27)	20 (13, 33)	20 (13, 34)
	post_p	NA (NA, NA)	0.5 (0.12, 0.9)	0.46 (0.1, 0.88)	0.46 (0.1, 0.86)	0.48 (0.11, 0.89)
	rate	0.111 (0.102, 0.125)	0.112 (0.096, 0.133)	0.115 (0.099, 0.135)	0.114 (0.099, 0.134)	0.112 (0.097, 0.136)
DRD+	graduation	0	5	0	1	1
	futility	0	2	39	58	36
	max_n	0	0	0	0	0
	n	108 (90, 124)	40 (23, 61)	50 (29, 73)	56 (37, 78)	58 (41, 80)
	n_unique	99 (81, 114)	36 (20, 57)	45 (27, 67)	51 (34, 72)	54 (37, 74)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (29, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	20 (19, 25)	26 (18, 33)	20 (13, 32)	21 (12, 31)
	post_p	NA (NA, NA)	0.63 (0.18, 0.97)	0.21 (0.02, 0.64)	0.2 (0.02, 0.68)	0.21 (0.03, 0.68)
	rate	0.096 (0.083, 0.112)	0.09 (0.068, 0.123)	0.115 (0.094, 0.145)	0.114 (0.095, 0.14)	0.112 (0.095, 0.139)
TEfus+	graduation	0	8	3	2	3
	futility	0	6	61	43	40
	max_n	0	1	0	0	0
	n	147 (126, 168)	58 (29, 88)	75 (43, 101)	70 (45, 95)	71 (48, 96)
	n_unique	136 (116, 154)	53 (25, 81)	69 (39, 93)	63 (41, 87)	64 (43, 89)
	time_trial	36 (36, 36)	36 (36, 36)	36 (30, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	20 (13, 27)	20 (10, 34)	24 (15, 32)	25 (13, 34)
	post_p	NA (NA, NA)	0.71 (0.26, 0.97)	0.24 (0.02, 0.66)	0.23 (0.03, 0.7)	0.25 (0.03, 0.73)
	rate	0.1 (0.089, 0.113)	0.092 (0.071, 0.112)	0.114 (0.097, 0.137)	0.114 (0.096, 0.141)	0.112 (0.096, 0.139)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	441	396	409	403
	futility	0	0	0	0	0
	max_n	0	50	18	19	25
	n	111 (72, 136)	27 (20, 105)	22 (9, 77)	18 (8, 82)	22 (9, 89)
	n_unique	104 (66, 128)	26 (18, 99)	20 (8, 74)	17 (7, 78)	20 (8, 84)
	post_p	NA (NA, NA)	1 (0.91, 1)	0.08 (0, 0.33)	0.07 (0.01, 0.3)	0.07 (0, 0.3)
	rate	0.075 (0.063, 0.087)	0.042 (0.032, 0.053)	0.115 (0.091, 0.172)	0.119 (0.091, 0.181)	0.117 (0.092, 0.166)
—+	graduation	0	442	404	412	408
	futility	0	0	0	0	0
	max_n	0	50	18	19	25
	n	19 (11, 27)	4 (1, 15)	7 (3, 19)	6 (2, 17)	6 (2, 18)
	n_unique	18 (10, 25)	4 (1, 14)	6 (3, 17)	6 (2, 15)	6 (2, 16)
	post_p	NA (NA, NA)	0.82 (0.5, 0.97)	0.28 (0.1, 0.57)	0.28 (0.1, 0.56)	0.3 (0.11, 0.57)
	rate	0.075 (0.049, 0.11)	0.042 (0.019, 0.085)	0.124 (0.081, 0.238)	0.13 (0.078, 0.3)	0.124 (0.074, 0.291)
–+-	graduation	0	70	42	30	28
	futility	0	0	0	0	0
	max_n	0	4	11	10	7
	n	61 (49, 76)	24 (9, 56)	25 (7, 53)	24 (8, 55)	24 (7, 56)
	n_unique	57 (44, 70)	23 (8, 53)	23 (7, 50)	23 (7, 51)	22 (7, 52)
	post_p	NA (NA, NA)	0.46 (0.11, 0.89)	0.43 (0.11, 0.84)	0.44 (0.12, 0.84)	0.42 (0.11, 0.87)
	rate	0.112 (0.094, 0.134)	0.115 (0.088, 0.182)	0.12 (0.093, 0.212)	0.119 (0.091, 0.198)	0.121 (0.089, 0.21)
–++	graduation	0	82	94	67	63
	futility	0	0	0	0	0
	max_n	0	5	11	10	7
	n	42 (32, 52)	14 (4, 36)	19 (8, 39)	17 (5, 34)	16 (5, 35)
	n_unique	39 (28, 49)	13 (4, 33)	17 (7, 36)	15 (4, 33)	15 (4, 33)
	post_p	NA (NA, NA)	0.44 (0.15, 0.85)	0.44 (0.13, 0.84)	0.46 (0.13, 0.88)	0.44 (0.14, 0.87)
	rate	0.113 (0.091, 0.142)	0.123 (0.085, 0.228)	0.122 (0.091, 0.185)	0.121 (0.085, 0.236)	0.121 (0.085, 0.25)
-+–	graduation	0	441	402	414	408
	futility	0	0	0	0	0
	max_n	0	50	17	19	25
	n	20 (11, 27)	2 (0, 12)	7 (2, 18)	8 (3, 18)	7 (3, 19)
	n_unique	18 (10, 25)	2 (0, 11)	6 (2, 17)	7 (3, 17)	7 (3, 17)
	post_p	NA (NA, NA)	0.77 (0.43, 0.96)	0.28 (0.12, 0.6)	0.27 (0.1, 0.6)	0.27 (0.11, 0.59)
	rate	0.075 (0.053, 0.109)	0.045 (0.012, 0.117)	0.125 (0.078, 0.283)	0.123 (0.079, 0.257)	0.122 (0.081, 0.234)
-+-+	graduation	0	442	408	417	413
	futility	0	0	0	0	0
	max_n	0	50	17	19	25
	n	20 (11, 27)	2 (0, 13)	6 (2, 18)	7 (3, 18)	7 (3, 19)
	n_unique	18 (10, 25)	2 (0, 13)	6 (2, 17)	7 (3, 17)	7 (3, 18)
	post_p	NA (NA, NA)	0.77 (0.44, 0.96)	0.29 (0.11, 0.58)	0.26 (0.1, 0.55)	0.27 (0.1, 0.58)
	rate	0.075 (0.051, 0.11)	0.044 (0.013, 0.12)	0.124 (0.08, 0.286)	0.128 (0.078, 0.271)	0.12 (0.079, 0.236)
-++-	graduation	0	77	73	82	55
	futility	0	0	0	0	0
	max_n	0	4	11	10	7
	n	11 (7, 16)	4 (1, 10)	5 (1, 10)	5 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 9)	4 (1, 9)	5 (2, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.48 (0.24, 0.79)	0.44 (0.22, 0.77)	0.46 (0.22, 0.78)	0.51 (0.22, 0.82)
	rate	0.116 (0.075, 0.186)	0.125 (0.068, 0.363)	0.142 (0.068, 0.39)	0.127 (0.072, 0.327)	0.118 (0.071, 0.283)
-+++	graduation	0	89	120	115	86
	futility	0	0	0	0	0
	max_n	0	5	11	10	7
	n	11 (7, 16)	4 (1, 10)	5 (1, 10)	6 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 9)	4 (1, 10)	5 (2, 11)	6 (2, 11)
	post_p	NA (NA, NA)	0.45 (0.24, 0.78)	0.44 (0.24, 0.79)	0.45 (0.21, 0.81)	0.45 (0.21, 0.81)
	rate	0.116 (0.075, 0.182)	0.134 (0.07, 0.363)	0.132 (0.067, 0.408)	0.126 (0.073, 0.308)	0.129 (0.071, 0.325)
+—	graduation	0	33	6	3	1
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	19 (13, 26)	8 (3, 18)	11 (5, 20)	8 (3, 17)	8 (3, 18)
	n_unique	17 (12, 23)	7 (2, 16)	10 (4, 18)	8 (3, 15)	8 (3, 16)
	post_p	NA (NA, NA)	0.45 (0.19, 0.79)	0.49 (0.19, 0.84)	0.46 (0.18, 0.86)	0.48 (0.18, 0.85)
	rate	0.112 (0.084, 0.164)	0.125 (0.08, 0.268)	0.12 (0.081, 0.222)	0.119 (0.075, 0.337)	0.125 (0.07, 0.311)
+–+	graduation	0	47	68	48	44
	futility	0	0	0	0	0
	max_n	0	1	0	0	0
	n	16 (10, 21)	7 (2, 15)	8 (4, 16)	6 (2, 13)	7 (2, 15)
	n_unique	14 (9, 20)	6 (2, 14)	8 (3, 16)	6 (2, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.48 (0.21, 0.85)	0.48 (0.18, 0.82)	0.45 (0.2, 0.8)	0.44 (0.21, 0.82)
	rate	0.116 (0.075, 0.17)	0.121 (0.071, 0.299)	0.123 (0.081, 0.254)	0.129 (0.067, 0.321)	0.124 (0.072, 0.317)
+-+-	graduation	0	70	42	30	28
	futility	0	0	0	0	0
	max_n	0	4	11	10	7
	n	15 (10, 21)	6 (2, 14)	8 (3, 15)	7 (3, 14)	7 (2, 15)
	n_unique	14 (9, 20)	5 (2, 13)	7 (2, 14)	6 (3, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.47 (0.2, 0.83)	0.47 (0.2, 0.8)	0.45 (0.2, 0.83)	0.47 (0.23, 0.82)
	rate	0.116 (0.081, 0.165)	0.122 (0.072, 0.323)	0.119 (0.076, 0.267)	0.125 (0.074, 0.273)	0.127 (0.07, 0.292)
+-++	graduation	0	82	94	67	63
	futility	0	0	0	0	0
	max_n	0	5	11	10	7
	n	16 (10, 22)	6 (2, 14)	8 (3, 16)	7 (2, 15)	7 (2, 16)
	n_unique	14 (9, 20)	5 (1, 13)	7 (2, 15)	6 (2, 13)	6 (2, 14)
	post_p	NA (NA, NA)	0.45 (0.19, 0.84)	0.48 (0.2, 0.82)	0.42 (0.19, 0.83)	0.48 (0.21, 0.84)
	rate	0.116 (0.081, 0.169)	0.128 (0.073, 0.358)	0.122 (0.076, 0.272)	0.135 (0.076, 0.335)	0.12 (0.073, 0.348)
++–	graduation	0	40	44	60	37
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 16)	5 (1, 10)	5 (2, 11)	6 (2, 11)	6 (3, 11)
	n_unique	10 (6, 15)	4 (1, 9)	5 (2, 10)	5 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.45 (0.24, 0.82)	0.46 (0.23, 0.81)	0.46 (0.21, 0.79)	0.47 (0.21, 0.83)
	rate	0.114 (0.077, 0.187)	0.127 (0.066, 0.316)	0.124 (0.067, 0.288)	0.125 (0.073, 0.306)	0.123 (0.07, 0.28)
++-+	graduation	0	54	99	97	72
	futility	0	0	0	0	0
	max_n	0	1	0	0	0
	n	11 (6, 16)	5 (1, 10)	5 (2, 11)	6 (2, 12)	5 (2, 13)
	n_unique	10 (6, 15)	4 (1, 10)	4 (1, 10)	5 (2, 11)	5 (2, 12)
	post_p	NA (NA, NA)	0.47 (0.24, 0.78)	0.47 (0.23, 0.8)	0.46 (0.21, 0.8)	0.47 (0.21, 0.8)
	rate	0.114 (0.074, 0.183)	0.127 (0.068, 0.297)	0.13 (0.066, 0.37)	0.131 (0.075, 0.338)	0.128 (0.073, 0.309)
+++-	graduation	0	77	73	82	55
	futility	0	0	0	0	0
	max_n	0	4	11	10	7
	n	11 (6, 16)	5 (1, 11)	5 (2, 11)	6 (2, 12)	6 (2, 12)
	n_unique	10 (6, 15)	4 (1, 10)	5 (1, 10)	6 (2, 11)	5 (2, 12)
	post_p	NA (NA, NA)	0.47 (0.22, 0.83)	0.44 (0.22, 0.81)	0.45 (0.21, 0.77)	0.46 (0.2, 0.79)
	rate	0.113 (0.071, 0.18)	0.128 (0.065, 0.348)	0.134 (0.065, 0.349)	0.129 (0.076, 0.329)	0.13 (0.072, 0.327)
++++	graduation	0	89	120	115	86
	futility	0	0	0	0	0
	max_n	0	5	11	10	7
	n	11 (7, 17)	5 (1, 11)	5 (1, 11)	6 (2, 12)	6 (2, 11)
	n_unique	10 (6, 15)	4 (1, 10)	4 (1, 10)	6 (2, 11)	5 (2, 11)
	post_p	NA (NA, NA)	0.47 (0.23, 0.83)	0.44 (0.23, 0.79)	0.48 (0.23, 0.81)	0.46 (0.22, 0.8)
	rate	0.114 (0.075, 0.186)	0.125 (0.063, 0.348)	0.13 (0.067, 0.383)	0.124 (0.071, 0.271)	0.124 (0.072, 0.306)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	29	2	1
	time_stop	5 (4, 8)	6 (5, 7)	6 (6, 6)
	n_trt	34 (27, 49)	30 (26, 35)	31 (31, 31)
	n_control	51 (43, 77)	66 (56, 77)	57 (57, 57)
	post_p	0.95 (0.87, 0.99)	0.94 (0.9, 0.98)	0.9 (0.9, 0.9)
	order	1 (1, 1.2)	1 (1, 1)	1 (1, 1)
TP53- & AR-	count	414	6	3	2
	time_stop	10 (7, 22)	12 (10, 14)	12 (11, 13)	12 (11, 14)
	n_trt	34 (26, 90)	29 (27, 37)	28 (26, 30)	28 (28, 29)
	n_control	41 (27, 101)	48 (46, 56)	36 (35, 41)	64 (53, 76)
	post_p	0.95 (0.88, 1)	0.91 (0.89, 0.95)	0.88 (0.86, 0.92)	0.92 (0.87, 0.98)
	order	1 (1, 1)	1.5 (1, 2)	1 (1, 1.8)	2 (2, 2)
TP53+	count	6		3	2
	time_stop	10 (10, 14)		17 (12, 31)	16 (14, 18)
	n_trt	36 (30, 48)		44 (34, 108)	34 (30, 38)
	n_control	48 (43, 62)		82 (47, 148)	79 (70, 88)
	post_p	0.97 (0.93, 0.98)		0.99 (0.99, 1)	0.94 (0.93, 0.95)
	order	2 (1, 2)		2 (1.2, 2)	2 (2, 2)
DRD+	count	5		1	1
	time_stop	20 (19, 22)		15 (15, 15)	11 (11, 11)
	n_trt	28 (27, 37)		25 (25, 25)	25 (25, 25)
	n_control	56 (49, 71)		42 (42, 42)	26 (26, 26)
	post_p	0.98 (0.92, 0.99)		1 (1, 1)	0.94 (0.94, 0.94)
	order	2 (1.4, 2)		2 (2, 2)	2 (2, 2)
TEfus+	count	8	3	2	3
	time_stop	20 (16, 25)	8 (6, 13)	12 (11, 12)	11 (11, 14)
	n_trt	36 (26, 50)	26 (25, 33)	28 (28, 28)	27 (26, 28)
	n_control	78 (60, 98)	30 (26, 44)	37 (31, 43)	45 (39, 48)
	post_p	0.98 (0.93, 1)	0.96 (0.94, 0.98)	0.99 (0.98, 0.99)	0.93 (0.89, 0.98)
	order	2 (1.7, 2.3)	2 (1.2, 2.8)	1.5 (1.1, 1.9)	2 (2, 2)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	4	4	2	1
	time_stop	4 (3, 4)	16 (9, 27)	24 (20, 28)	22 (22, 22)
	n_trt	28 (27, 29)	72 (47, 103)	83 (71, 95)	84 (84, 84)
	n_control	38 (33, 42)	186 (95, 292)	250 (234, 266)	249 (249, 249)
	post_p	0.25 (0.19, 0.27)	0.02 (0, 0.03)	0.01 (0, 0.02)	0.01 (0.01, 0.01)
	order	1 (1, 1)	3 (1.3, 5.4)	4.5 (3.3, 5.7)	3 (3, 3)
TP53- & AR-	count	1	386	405	401
	time_stop	9 (9, 9)	21 (13, 33)	20 (13, 32)	20 (13, 32)
	n_trt	25 (25, 25)	37 (25, 100)	35 (25, 96)	39 (25, 94)
	n_control	26 (26, 26)	100 (57, 170)	100 (56, 165)	96 (54, 164)
	post_p	0.26 (0.26, 0.26)	0.06 (0, 0.2)	0.05 (0, 0.19)	0.06 (0, 0.19)
	order	1 (1, 1)	2 (1, 4)	2 (1, 4)	2 (1, 4)
TP53+	count	31	39	26	26
	time_stop	16 (10, 30)	19 (13, 27)	20 (13, 32)	22 (13, 34)
	n_trt	36 (25, 70)	41 (27, 68)	40 (25, 62)	43 (26, 58)
	n_control	79 (37, 147)	90 (51, 128)	87 (52, 152)	104 (62, 170)
	post_p	0.05 (0.02, 0.15)	0.08 (0.04, 0.22)	0.06 (0.01, 0.16)	0.04 (0, 0.14)
	order	1 (1, 4)	2 (1, 4)	2.5 (1, 5)	2 (1, 5)
DRD+	count	2	39	58	36
	time_stop	24 (21, 28)	26 (18, 33)	20 (13, 32)	21 (12, 31)
	n_trt	28 (26, 30)	29 (25, 46)	36 (26, 50)	32 (25, 63)
	n_control	78 (61, 95)	75 (47, 107)	58 (30, 95)	59 (28, 99)
	post_p	0.04 (0.04, 0.04)	0.04 (0, 0.16)	0.04 (0, 0.15)	0.04 (0, 0.19)
	order	3 (2.2, 3.8)	3 (2, 4.2)	3 (1, 4.3)	3 (1, 4.5)
TEfus+	count	6	61	43	40
	time_stop	20 (12, 26)	21 (11, 34)	24 (16, 33)	26 (15, 34)
	n_trt	30 (25, 37)	41 (26, 70)	39 (26, 58)	47 (28, 78)
	n_control	90 (42, 114)	82 (40, 129)	96 (60, 131)	108 (53, 137)
	post_p	0.06 (0.02, 0.11)	0.04 (0, 0.15)	0.04 (0.01, 0.14)	0.05 (0.01, 0.12)
	order	2 (1, 3.5)	3 (1, 5)	3 (1.2, 5)	4 (2, 6)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	29	29	29	29	29	29	29	29	29	29	29	29	29	29	29	29
		time	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)	5 (4, 8)
		n	17 (11, 25)	2 (1, 5)	8 (4, 11)	3 (0, 5)	0 (0, 1)	0 (0, 1)	0 (0, 1)	0 (0, 1)	1 (0, 3)	1 (0, 2)	0 (0, 3)	0 (0, 2)	0 (0, 2)	0 (0, 0)	0 (0, 1)	0 (0, 1)
		post_p	0.66 (0.56, 0.9)	0.55 (0.51, 0.64)	0.59 (0.52, 0.71)	0.55 (0.52, 0.66)	0.57 (0.54, 0.59)	0.53 (0.51, 0.6)	0.58 (0.53, 0.72)	0.52 (0.5, 0.54)	0.54 (0.52, 0.58)	0.54 (0.52, 0.58)	0.56 (0.53, 0.57)	0.52 (0.51, 0.6)	0.54 (0.52, 0.58)	0.52 (0.52, 0.6)	0.54 (0.53, 0.62)	0.55 (0.53, 0.57)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.027 (0.005, 0.061)	0 (0, 0.021)	0.08 (0, 0.113)	0 (0, 0.104)	0 (0, 0.027)	0 (0, 0)	0 (0, 0.137)	0 (0, 1.004)	0 (0, 0.083)	0 (0, 0.271)	0 (0, 0.064)	0 (0, 0)	0 (0, 0.01)	0 (0, 0.05)	0 (0, 0)	0 (0, 0.313)
	Taxel_therapies	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)	6 (5, 7)
		n	3 (1, 5)	2 (0, 3)	4 (3, 4)	6 (5, 7)	0 (0, 1)	0 (0, 0)	0 (0, 1)	1 (0, 2)	3 (2, 4)	4 (2, 6)	2 (2, 2)	4 (4, 5)	0 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 1)
		post_p	0.62 (0.62, 0.62)	0.58 (0.58, 0.58)	0.56 (0.55, 0.57)	0.55 (0.53, 0.58)	0.55 (0.55, 0.55)	NA (NA, NA)	0.55 (0.55, 0.55)	0.52 (0.52, 0.52)	0.54 (0.53, 0.55)	0.6 (0.55, 0.65)	0.57 (0.53, 0.61)	0.58 (0.58, 0.58)	0.54 (0.54, 0.54)	NA (NA, NA)	0.52 (0.52, 0.52)	0.53 (0.53, 0.53)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0 (0, 0)	0 (0, 0)	0.055 (0.011, 0.099)	0.048 (0.01, 0.087)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.035 (0.007, 0.063)	0.019 (0.004, 0.034)	0 (0, 0)	0.065 (0.013, 0.117)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)
	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)	6 (6, 6)
		n	8 (8, 8)	0 (0, 0)	5 (5, 5)	0 (0, 0)	1 (1, 1)	6 (6, 6)	2 (2, 2)	1 (1, 1)	2 (2, 2)	0 (0, 0)	0 (0, 0)	0 (0, 0)	2 (2, 2)	1 (1, 1)	2 (2, 2)	1 (1, 1)
		post_p	0.67 (0.67, 0.67)	NA (NA, NA)	0.56 (0.56, 0.56)	NA (NA, NA)	NA (NA, NA)	0.56 (0.56, 0.56)	0.52 (0.52, 0.52)	0.57 (0.57, 0.57)	0.51 (0.51, 0.51)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	0.56 (0.56, 0.56)	0.57 (0.57, 0.57)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0 (0, 0)	NA (NA, NA)	0.06 (0.06, 0.06)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.308 (0.308, 0.308)	0.922 (0.922, 0.922)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53- & AR-	Hormone_therapies	count	414	414			414	414
		time	10 (7, 22)	10 (7, 22)			10 (7, 22)	10 (7, 22)
		n	26 (20, 64)	4 (1, 11)			2 (0, 8)	2 (0, 8)
		post_p	0.87 (0.74, 1)	0.6 (0.52, 0.8)			0.58 (0.51, 0.86)	0.58 (0.51, 0.84)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.037 (0.016, 0.056)	0.017 (0, 0.074)			0 (0, 0.073)	0 (0, 0.07)
	Taxel_therapies	count	6	6			6	6
		time	12 (10, 14)	12 (10, 14)			12 (10, 14)	12 (10, 14)
		n	23 (18, 28)	4 (1, 5)			2 (0, 6)	2 (0, 4)
		post_p	0.76 (0.75, 0.91)	0.61 (0.52, 0.75)			0.61 (0.56, 0.7)	0.56 (0.53, 0.58)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.053 (0.031, 0.076)	0.014 (0, 0.045)			0 (0, 0.029)	0 (0, 0.081)
	Carboplatin	count	3	3			3	3
		time	12 (11, 13)	12 (11, 13)			12 (11, 13)	12 (11, 13)
		n	16 (14, 18)	4 (3, 5)			5 (3, 5)	3 (3, 5)
		post_p	0.84 (0.84, 0.84)	0.61 (0.54, 0.61)			0.61 (0.57, 0.66)	0.55 (0.52, 0.68)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.033 (0.03, 0.035)	0.055 (0.011, 0.088)			0.067 (0.037, 0.072)	0.083 (0.036, 0.1)
	Niraparib	count	2	2			2	2
		time	12 (11, 14)	12 (11, 14)			12 (11, 14)	12 (11, 14)
		n	10 (5, 16)	4 (4, 5)			6 (4, 8)	8 (6, 10)
		post_p	0.66 (0.62, 0.71)	0.66 (0.65, 0.67)			0.65 (0.56, 0.75)	0.64 (0.57, 0.7)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.053 (0.039, 0.067)	0 (0, 0)			0.054 (0.011, 0.098)	0.04 (0.035, 0.044)
TP53+	Hormone_therapies	count			6	6			6	6			6	6			6	6
		time			10 (10, 14)	10 (10, 14)			10 (10, 14)	10 (10, 14)			10 (10, 14)	10 (10, 14)			10 (10, 14)	10 (10, 14)
		n			18 (13, 20)	6 (4, 10)			2 (2, 4)	2 (0, 4)			3 (1, 4)	2 (0, 6)			2 (0, 5)	2 (0, 5)
		post_p			0.79 (0.71, 0.86)	0.72 (0.63, 0.89)			0.59 (0.54, 0.68)	0.63 (0.55, 0.78)			0.55 (0.52, 0.6)	0.58 (0.52, 0.8)			0.57 (0.54, 0.58)	0.6 (0.56, 0.8)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.076 (0.049, 0.09)	0.048 (0.038, 0.093)			0 (0, 0.087)	0.013 (0, 0.066)			0.033 (0, 0.125)	0.051 (0, 0.095)			0.125 (0, 0.192)	0.088 (0.018, 0.09)
	Carboplatin	count			3	3			3	3			3	3			3	3
		time			17 (12, 31)	17 (12, 31)			17 (12, 31)	17 (12, 31)			17 (12, 31)	17 (12, 31)			17 (12, 31)	17 (12, 31)
		n			16 (10, 38)	7 (5, 25)			4 (4, 5)	5 (3, 5)			4 (3, 9)	1 (1, 19)			4 (2, 7)	4 (2, 4)
		post_p			0.8 (0.79, 0.82)	0.82 (0.79, 0.83)			0.54 (0.53, 0.6)	0.58 (0.55, 0.79)			0.65 (0.64, 0.7)	0.62 (0.55, 0.9)			0.79 (0.59, 0.82)	0.62 (0.54, 0.66)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.083 (0.074, 0.092)	0.083 (0.017, 0.097)			0.128 (0.098, 0.19)	0.069 (0.044, 0.104)			0.033 (0.007, 0.093)	0 (0, 0.066)			0.044 (0.009, 0.05)	0.105 (0.021, 0.132)
	Niraparib	count			2	2			2	2			2	2			2	2
		time			16 (14, 18)	16 (14, 18)			16 (14, 18)	16 (14, 18)			16 (14, 18)	16 (14, 18)			16 (14, 18)	16 (14, 18)
		n			10 (8, 11)	6 (6, 6)			4 (3, 6)	2 (2, 3)			4 (2, 6)	1 (0, 2)			2 (1, 4)	4 (4, 5)
		post_p			0.8 (0.75, 0.85)	0.75 (0.72, 0.78)			0.65 (0.59, 0.71)	0.54 (0.53, 0.54)			0.67 (0.56, 0.78)	0.56 (0.56, 0.56)			0.53 (0.51, 0.56)	0.71 (0.68, 0.73)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.056 (0.049, 0.063)	0.031 (0.006, 0.056)			0.088 (0.065, 0.112)	0.133 (0.12, 0.147)			0.035 (0.007, 0.064)	0.117 (0.117, 0.117)			0.03 (0.006, 0.054)	0.097 (0.056, 0.138)
DRD+	Hormone_therapies	count					5	5	5	5					5	5	5	5
		time					20 (19, 22)	20 (19, 22)	20 (19, 22)	20 (19, 22)					20 (19, 22)	20 (19, 22)	20 (19, 22)	20 (19, 22)
		n					1 (0, 3)	4 (2, 7)	4 (3, 9)	3 (1, 6)					3 (1, 6)	4 (1, 8)	5 (4, 7)	3 (1, 6)
		post_p					0.52 (0.51, 0.71)	0.75 (0.58, 0.86)	0.79 (0.72, 0.83)	0.66 (0.53, 0.74)					0.59 (0.53, 0.72)	0.58 (0.56, 0.86)	0.65 (0.64, 0.78)	0.66 (0.55, 0.85)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.056 (0.011, 0.088)	0.024 (0.009, 0.083)	0.033 (0.012, 0.08)	0.064 (0.012, 0.108)					0.071 (0.025, 0.092)	0 (0, 0.068)	0.057 (0.055, 0.072)	0.022 (0, 0.09)
	Carboplatin	count					1	1	1	1					1	1	1	1
		time					15 (15, 15)	15 (15, 15)	15 (15, 15)	15 (15, 15)					15 (15, 15)	15 (15, 15)	15 (15, 15)	15 (15, 15)
		n					5 (5, 5)	7 (7, 7)	0 (0, 0)	4 (4, 4)					5 (5, 5)	2 (2, 2)	1 (1, 1)	1 (1, 1)
		post_p					0.62 (0.62, 0.62)	0.85 (0.85, 0.85)	NA (NA, NA)	0.82 (0.82, 0.82)					0.8 (0.8, 0.8)	0.6 (0.6, 0.6)	0.6 (0.6, 0.6)	0.57 (0.57, 0.57)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.072 (0.072, 0.072)	0.022 (0.022, 0.022)	NA (NA, NA)	0.035 (0.035, 0.035)					0.025 (0.025, 0.025)	0.115 (0.115, 0.115)	0 (0, 0)	0 (0, 0)
	Niraparib	count					1	1	1	1					1	1	1	1
		time					11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)					11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)
		n					2 (2, 2)	3 (3, 3)	2 (2, 2)	3 (3, 3)					5 (5, 5)	3 (3, 3)	3 (3, 3)	4 (4, 4)
		post_p					0.61 (0.61, 0.61)	0.59 (0.59, 0.59)	0.55 (0.55, 0.55)	0.52 (0.52, 0.52)					0.58 (0.58, 0.58)	0.56 (0.56, 0.56)	0.58 (0.58, 0.58)	0.66 (0.66, 0.66)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0 (0, 0)	0 (0, 0)	0 (0, 0)	0.128 (0.128, 0.128)					0.036 (0.036, 0.036)	0 (0, 0)	0 (0, 0)	0.094 (0.094, 0.094)
TEfus+	Hormone_therapies	count		8		8		8		8		8		8		8		8
		time		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)		20 (16, 25)
		n		4 (2, 8)		12 (8, 15)		3 (0, 5)		4 (1, 5)		4 (2, 6)		4 (1, 11)		4 (1, 8)		4 (1, 5)
		post_p		0.77 (0.6, 0.93)		0.82 (0.71, 0.88)		0.81 (0.67, 0.91)		0.62 (0.5, 0.75)		0.6 (0.53, 0.72)		0.58 (0.51, 0.8)		0.71 (0.57, 0.79)		0.56 (0.53, 0.78)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.035 (0, 0.07)		0.083 (0.05, 0.088)		0.007 (0, 0.041)		0.062 (0.037, 0.111)		0.089 (0.06, 0.105)		0.088 (0, 0.135)		0 (0, 0.094)		0.079 (0, 0.095)
	Taxel_therapies	count		3		3		3		3		3		3		3		3
		time		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)		8 (6, 13)
		n		1 (0, 3)		14 (11, 19)		1 (0, 3)		1 (0, 3)		4 (4, 4)		3 (3, 5)		0 (0, 2)		1 (0, 2)
		post_p		0.6 (0.52, 0.67)		0.8 (0.77, 0.83)		0.53 (0.53, 0.53)		0.6 (0.57, 0.63)		0.54 (0.51, 0.65)		0.55 (0.52, 0.58)		0.64 (0.64, 0.64)		0.59 (0.59, 0.59)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.038 (0.008, 0.068)		0.051 (0.028, 0.082)		0.072 (0.014, 0.13)		0 (0, 0)		0 (0, 0.037)		0.065 (0.039, 0.079)		0 (0, 0)		0 (0, 0)
	Carboplatin	count		2		2		2		2		2		2		2		2
		time		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)		12 (11, 12)
		n		4 (4, 5)		8 (8, 9)		7 (5, 9)		2 (2, 2)		2 (0, 3)		0 (0, 0)		3 (3, 3)		2 (0, 3)
		post_p		0.62 (0.6, 0.64)		0.79 (0.75, 0.83)		0.71 (0.63, 0.78)		0.61 (0.6, 0.61)		0.6 (0.6, 0.6)		NA (NA, NA)		0.54 (0.53, 0.55)		0.68 (0.68, 0.68)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.024 (0.005, 0.043)		0.043 (0.037, 0.048)		0.035 (0.026, 0.043)		0.027 (0.005, 0.048)		0 (0, 0)		NA (NA, NA)		0.057 (0.049, 0.065)		0 (0, 0)
	Niraparib	count		3		3		3		3		3		3		3		3
		time		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)		11 (11, 14)
		n		1 (1, 6)		4 (3, 6)		5 (5, 5)		2 (2, 6)		3 (1, 4)		1 (1, 3)		3 (3, 5)		3 (2, 5)
		post_p		0.61 (0.54, 0.8)		0.64 (0.6, 0.74)		0.54 (0.51, 0.62)		0.73 (0.66, 0.82)		0.68 (0.6, 0.75)		0.57 (0.56, 0.58)		0.65 (0.56, 0.72)		0.56 (0.52, 0.66)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0.049)		0.043 (0.009, 0.097)		0.08 (0.016, 0.101)		0 (0, 0.099)		0 (0, 0)		0 (0, 0)		0.062 (0.058, 0.105)		0.071 (0.014, 0.082)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)	4 (3, 4)
		n	14 (12, 17)	3 (1, 5)	6 (5, 6)	3 (2, 3)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)	2 (1, 2)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 1)
		post_p	0.44 (0.37, 0.48)	0.42 (0.4, 0.43)	0.44 (0.39, 0.47)	0.42 (0.38, 0.47)	NA (NA, NA)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	0.44 (0.43, 0.47)	NA (NA, NA)	0.41 (0.41, 0.41)	0.48 (0.48, 0.48)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.47 (0.47, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.076 (0.05, 0.094)	0.056 (0, 0.256)	0.232 (0.205, 0.25)	0.208 (0.054, 1.418)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	0.095 (0, 0.588)	NA (NA, NA)	1.414 (1.414, 1.414)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)
	Taxel_therapies	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)	16 (9, 27)
		n	12 (6, 32)	4 (2, 6)	6 (3, 9)	8 (7, 12)	4 (0, 10)	4 (1, 6)	2 (1, 3)	0 (0, 1)	8 (6, 12)	6 (5, 7)	6 (4, 7)	2 (1, 4)	2 (2, 3)	0 (0, 2)	1 (0, 2)	2 (0, 3)
		post_p	0.11 (0.02, 0.16)	0.35 (0.27, 0.36)	0.33 (0.2, 0.43)	0.44 (0.44, 0.46)	0.37 (0.32, 0.45)	0.42 (0.3, 0.48)	0.33 (0.26, 0.36)	0.4 (0.4, 0.4)	0.4 (0.32, 0.43)	0.45 (0.21, 0.49)	0.4 (0.19, 0.44)	0.36 (0.35, 0.45)	0.41 (0.29, 0.48)	0.4 (0.36, 0.44)	0.4 (0.35, 0.44)	0.28 (0.21, 0.44)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.16 (0.126, 0.387)	0.151 (0.118, 0.547)	0.18 (0.168, 0.243)	0.102 (0.099, 0.131)	0.134 (0.116, 0.293)	0.095 (0.06, 0.232)	0.312 (0.2, 0.332)	0.467 (0.467, 0.467)	0.13 (0.107, 0.169)	0.127 (0.094, 0.504)	0.109 (0.094, 0.534)	0.162 (0.111, 0.269)	0.238 (0.196, 0.313)	0.469 (0.267, 0.672)	0.31 (0.281, 0.339)	0.514 (0.151, 1.106)
	Carboplatin	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
		time	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)	24 (20, 28)
		n	26 (13, 38)	7 (6, 8)	10 (8, 13)	2 (1, 4)	10 (8, 12)	2 (1, 2)	2 (1, 3)	2 (2, 3)	4 (4, 4)	2 (2, 3)	2 (1, 4)	2 (1, 4)	2 (2, 3)	2 (2, 3)	2 (1, 3)	3 (3, 3)
		post_p	0.18 (0.09, 0.27)	0.14 (0.1, 0.18)	0.4 (0.35, 0.46)	0.31 (0.24, 0.39)	0.27 (0.15, 0.39)	0.3 (0.29, 0.31)	0.33 (0.27, 0.38)	0.4 (0.35, 0.44)	0.35 (0.3, 0.39)	0.35 (0.3, 0.39)	0.22 (0.22, 0.22)	0.28 (0.28, 0.28)	0.41 (0.34, 0.48)	0.32 (0.31, 0.33)	0.37 (0.3, 0.45)	0.4 (0.32, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.13 (0.107, 0.152)	0.222 (0.147, 0.298)	0.122 (0.118, 0.127)	0.291 (0.235, 0.348)	0.14 (0.126, 0.155)	0.611 (0.263, 0.958)	0.321 (0.238, 0.405)	0.171 (0.082, 0.259)	0.193 (0.179, 0.208)	0.391 (0.208, 0.574)	0.25 (0.25, 0.25)	0.175 (0.175, 0.175)	0.186 (0.109, 0.262)	0.32 (0.303, 0.338)	0.285 (0.247, 0.322)	0.162 (0.108, 0.216)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)	22 (22, 22)
		n	25 (25, 25)	1 (1, 1)	12 (12, 12)	1 (1, 1)	11 (11, 11)	9 (9, 9)	1 (1, 1)	4 (4, 4)	2 (2, 2)	3 (3, 3)	3 (3, 3)	1 (1, 1)	5 (5, 5)	3 (3, 3)	2 (2, 2)	1 (1, 1)
		post_p	0.24 (0.24, 0.24)	0.36 (0.36, 0.36)	0.33 (0.33, 0.33)	0.31 (0.31, 0.31)	0.45 (0.45, 0.45)	0.35 (0.35, 0.35)	0.42 (0.42, 0.42)	0.35 (0.35, 0.35)	0.36 (0.36, 0.36)	0.39 (0.39, 0.39)	0.29 (0.29, 0.29)	0.42 (0.42, 0.42)	0.36 (0.36, 0.36)	0.49 (0.49, 0.49)	0.23 (0.23, 0.23)	0.38 (0.38, 0.38)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.107 (0.107, 0.107)	30.678 (30.678, 30.678)	0.145 (0.145, 0.145)	1.506 (1.506, 1.506)	0.082 (0.082, 0.082)	0.139 (0.139, 0.139)	0.221 (0.221, 0.221)	0.153 (0.153, 0.153)	0.575 (0.575, 0.575)	0.175 (0.175, 0.175)	0.268 (0.268, 0.268)	0.287 (0.287, 0.287)	0.112 (0.112, 0.112)	0.166 (0.166, 0.166)	0.326 (0.326, 0.326)	0.64 (0.64, 0.64)
TP53- & AR-	Hormone_therapies	count	1	1			1	1
		time	9 (9, 9)	9 (9, 9)			9 (9, 9)	9 (9, 9)
		n	18 (18, 18)	3 (3, 3)			1 (1, 1)	3 (3, 3)
		post_p	0.45 (0.45, 0.45)	0.45 (0.45, 0.45)			0.38 (0.38, 0.38)	0.47 (0.47, 0.47)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.087 (0.087, 0.087)	0.063 (0.063, 0.063)			0.214 (0.214, 0.214)	0.153 (0.153, 0.153)
	Taxel_therapies	count	386	386			386	386
		time	21 (13, 33)	21 (13, 33)			21 (13, 33)	21 (13, 33)
		n	20 (9, 59)	6 (3, 15)			6 (2, 15)	6 (2, 16)
		post_p	0.19 (0.03, 0.43)	0.34 (0.15, 0.48)			0.38 (0.17, 0.48)	0.38 (0.17, 0.48)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.114 (0.088, 0.176)	0.131 (0.082, 0.258)			0.134 (0.086, 0.298)	0.131 (0.084, 0.325)
	Carboplatin	count	405	405			405	405
		time	20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)
		n	17 (8, 59)	6 (2, 14)			7 (3, 15)	7 (3, 15)
		post_p	0.19 (0.02, 0.45)	0.38 (0.16, 0.48)			0.34 (0.12, 0.48)	0.34 (0.15, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.118 (0.09, 0.198)	0.137 (0.083, 0.328)			0.127 (0.085, 0.277)	0.128 (0.088, 0.287)
	Niraparib	count	401	401			401	401
		time	20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)
		n	19 (9, 63)	5 (2, 14)			7 (3, 15)	7 (3, 16)
		post_p	0.21 (0.03, 0.43)	0.38 (0.2, 0.48)			0.36 (0.18, 0.48)	0.37 (0.17, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.116 (0.087, 0.175)	0.128 (0.081, 0.344)			0.126 (0.078, 0.247)	0.122 (0.082, 0.25)
TP53+	Hormone_therapies	count			31	31			31	31			31	31			31	31
		time			16 (10, 30)	16 (10, 30)			16 (10, 30)	16 (10, 30)			16 (10, 30)	16 (10, 30)			16 (10, 30)	16 (10, 30)
		n			13 (8, 26)	7 (4, 16)			2 (0, 5)	2 (1, 5)			4 (1, 6)	4 (0, 5)			2 (0, 5)	2 (1, 7)
		post_p			0.24 (0.11, 0.45)	0.34 (0.18, 0.47)			0.43 (0.32, 0.48)	0.38 (0.25, 0.49)			0.4 (0.29, 0.48)	0.4 (0.15, 0.45)			0.4 (0.19, 0.46)	0.43 (0.32, 0.48)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.14 (0.108, 0.182)	0.148 (0.107, 0.293)			0.167 (0.109, 1.08)	0.194 (0.08, 1.276)			0.154 (0.108, 0.415)	0.163 (0.093, 0.385)			0.268 (0.114, 0.574)	0.165 (0.058, 0.871)
	Taxel_therapies	count			39	39			39	39			39	39			39	39
		time			19 (13, 27)	19 (13, 27)			19 (13, 27)	19 (13, 27)			19 (13, 27)	19 (13, 27)			19 (13, 27)	19 (13, 27)
		n			10 (5, 34)	10 (6, 17)			2 (0, 4)	2 (0, 5)			5 (2, 7)	3 (2, 8)			2 (0, 5)	2 (0, 5)
		post_p			0.34 (0.15, 0.47)	0.36 (0.14, 0.45)			0.37 (0.22, 0.47)	0.4 (0.28, 0.49)			0.4 (0.23, 0.47)	0.38 (0.27, 0.47)			0.41 (0.27, 0.49)	0.42 (0.23, 0.49)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.136 (0.098, 0.281)	0.13 (0.104, 0.205)			0.234 (0.109, 0.456)	0.237 (0.096, 0.897)			0.169 (0.088, 0.335)	0.162 (0.102, 0.517)			0.194 (0.101, 0.792)	0.256 (0.098, 0.611)
	Carboplatin	count			26	26			26	26			26	26			26	26
		time			20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)			20 (13, 32)	20 (13, 32)
		n			13 (6, 20)	5 (2, 16)			3 (1, 5)	3 (2, 6)			4 (2, 11)	2 (1, 5)			4 (0, 9)	3 (1, 7)
		post_p			0.35 (0.11, 0.43)	0.4 (0.14, 0.48)			0.39 (0.24, 0.48)	0.38 (0.18, 0.46)			0.36 (0.24, 0.49)	0.37 (0.2, 0.46)			0.37 (0.28, 0.47)	0.4 (0.25, 0.49)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.146 (0.113, 0.224)	0.142 (0.104, 0.402)			0.225 (0.095, 1.059)	0.174 (0.114, 0.274)			0.185 (0.104, 0.505)	0.178 (0.126, 0.436)			0.17 (0.101, 0.347)	0.174 (0.1, 0.293)
	Niraparib	count			26	26			26	26			26	26			26	26
		time			22 (13, 34)	22 (13, 34)			22 (13, 34)	22 (13, 34)			22 (13, 34)	22 (13, 34)			22 (13, 34)	22 (13, 34)
		n			11 (5, 26)	8 (4, 21)			2 (1, 5)	4 (1, 6)			3 (1, 6)	3 (1, 5)			4 (2, 7)	3 (0, 8)
		post_p			0.24 (0.09, 0.39)	0.37 (0.16, 0.47)			0.39 (0.22, 0.46)	0.34 (0.24, 0.44)			0.39 (0.2, 0.47)	0.39 (0.2, 0.47)			0.41 (0.26, 0.47)	0.39 (0.24, 0.47)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.157 (0.112, 0.336)	0.137 (0.11, 0.435)			0.224 (0.126, 0.562)	0.206 (0.116, 0.351)			0.198 (0.112, 0.369)	0.177 (0.106, 1.014)			0.154 (0.112, 0.32)	0.179 (0.093, 0.435)
DRD+	Hormone_therapies	count					2	2	2	2					2	2	2	2
		time					24 (21, 28)	24 (21, 28)	24 (21, 28)	24 (21, 28)					24 (21, 28)	24 (21, 28)	24 (21, 28)	24 (21, 28)
		n					2 (0, 4)	0 (0, 1)	4 (3, 5)	3 (2, 4)					4 (3, 5)	4 (4, 5)	4 (3, 4)	6 (3, 10)
		post_p					0.43 (0.43, 0.43)	0.41 (0.41, 0.41)	0.45 (0.43, 0.48)	0.36 (0.25, 0.47)					0.26 (0.15, 0.38)	0.36 (0.29, 0.42)	0.31 (0.29, 0.33)	0.43 (0.37, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.114 (0.114, 0.114)	0.099 (0.099, 0.099)	0.086 (0.061, 0.111)	0.169 (0.144, 0.195)					0.441 (0.333, 0.548)	0.14 (0.137, 0.142)	0.196 (0.195, 0.196)	0.16 (0.115, 0.204)
	Taxel_therapies	count					39	39	39	39					39	39	39	39
		time					26 (18, 33)	26 (18, 33)	26 (18, 33)	26 (18, 33)					26 (18, 33)	26 (18, 33)	26 (18, 33)	26 (18, 33)
		n					7 (3, 15)	6 (2, 16)	3 (1, 5)	2 (1, 5)					5 (2, 7)	3 (1, 5)	3 (1, 5)	3 (0, 7)
		post_p					0.36 (0.18, 0.47)	0.32 (0.12, 0.45)	0.35 (0.22, 0.48)	0.36 (0.23, 0.45)					0.42 (0.23, 0.48)	0.36 (0.21, 0.46)	0.36 (0.23, 0.46)	0.36 (0.17, 0.49)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.134 (0.092, 0.243)	0.148 (0.093, 0.472)	0.228 (0.115, 0.816)	0.288 (0.147, 0.65)					0.161 (0.092, 0.275)	0.232 (0.131, 0.429)	0.219 (0.125, 0.816)	0.192 (0.113, 0.446)
	Carboplatin	count					58	58	58	58					58	58	58	58
		time					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)					20 (13, 32)	20 (13, 32)	20 (13, 32)	20 (13, 32)
		n					6 (4, 15)	6 (2, 11)	4 (1, 7)	4 (1, 7)					4 (2, 7)	3 (2, 6)	4 (1, 6)	3 (2, 5)
		post_p					0.35 (0.12, 0.47)	0.33 (0.15, 0.43)	0.4 (0.24, 0.48)	0.39 (0.26, 0.48)					0.43 (0.26, 0.49)	0.4 (0.23, 0.47)	0.39 (0.2, 0.47)	0.38 (0.27, 0.47)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.135 (0.093, 0.265)	0.155 (0.1, 0.407)	0.156 (0.104, 0.447)	0.142 (0.092, 0.432)					0.16 (0.083, 0.279)	0.177 (0.109, 0.447)	0.168 (0.102, 0.44)	0.153 (0.102, 0.366)
	Niraparib	count					36	36	36	36					36	36	36	36
		time					21 (12, 31)	21 (12, 31)	21 (12, 31)	21 (12, 31)					21 (12, 31)	21 (12, 31)	21 (12, 31)	21 (12, 31)
		n					6 (4, 14)	6 (3, 16)	3 (2, 7)	4 (1, 7)					3 (1, 8)	4 (1, 6)	4 (1, 6)	3 (1, 8)
		post_p					0.3 (0.15, 0.42)	0.35 (0.14, 0.48)	0.37 (0.23, 0.49)	0.39 (0.23, 0.48)					0.36 (0.17, 0.46)	0.38 (0.26, 0.49)	0.4 (0.28, 0.48)	0.38 (0.21, 0.47)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.146 (0.091, 0.243)	0.13 (0.076, 0.286)	0.179 (0.092, 0.624)	0.183 (0.077, 0.462)					0.2 (0.1, 1.086)	0.173 (0.099, 0.485)	0.18 (0.126, 0.539)	0.178 (0.102, 0.607)
TEfus+	Hormone_therapies	count		6		6		6		6		6		6		6		6
		time		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)		20 (12, 26)
		n		4 (1, 6)		6 (2, 10)		2 (0, 6)		2 (0, 4)		3 (3, 8)		4 (2, 6)		4 (2, 4)		4 (2, 6)
		post_p		0.48 (0.42, 0.5)		0.34 (0.21, 0.44)		0.44 (0.34, 0.48)		0.39 (0.26, 0.41)		0.36 (0.19, 0.39)		0.37 (0.2, 0.47)		0.45 (0.34, 0.49)		0.42 (0.3, 0.49)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.089 (0.02, 0.11)		0.16 (0.131, 0.262)		0.13 (0.069, 0.176)		0.41 (0.14, 5.111)		0.2 (0.149, 0.493)		0.177 (0.122, 0.229)		0.173 (0.127, 0.23)		0.221 (0.081, 0.365)
	Taxel_therapies	count		61		61		61		61		61		61		61		61
		time		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)		21 (11, 34)
		n		5 (2, 11)		11 (6, 23)		4 (1, 10)		2 (0, 7)		5 (2, 10)		5 (2, 8)		2 (1, 5)		2 (0, 7)
		post_p		0.3 (0.12, 0.48)		0.33 (0.17, 0.46)		0.36 (0.17, 0.48)		0.41 (0.22, 0.48)		0.39 (0.23, 0.48)		0.4 (0.24, 0.49)		0.39 (0.22, 0.48)		0.4 (0.25, 0.48)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.144 (0.084, 0.266)		0.135 (0.108, 0.231)		0.155 (0.087, 0.388)		0.199 (0.116, 0.494)		0.152 (0.108, 0.364)		0.147 (0.105, 0.253)		0.229 (0.122, 0.634)		0.2 (0.118, 0.711)
	Carboplatin	count		43		43		43		43		43		43		43		43
		time		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)		24 (16, 33)
		n		5 (2, 8)		8 (3, 22)		6 (2, 11)		3 (2, 8)		4 (1, 7)		3 (1, 7)		3 (1, 7)		4 (1, 7)
		post_p		0.31 (0.17, 0.44)		0.4 (0.19, 0.49)		0.3 (0.16, 0.47)		0.35 (0.18, 0.48)		0.34 (0.2, 0.47)		0.42 (0.23, 0.49)		0.34 (0.18, 0.48)		0.37 (0.25, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.145 (0.108, 0.273)		0.138 (0.101, 0.373)		0.128 (0.086, 0.323)		0.185 (0.107, 0.373)		0.187 (0.122, 0.476)		0.159 (0.118, 0.372)		0.207 (0.12, 0.505)		0.172 (0.104, 0.579)
	Niraparib	count		40		40		40		40		40		40		40		40
		time		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)		26 (15, 34)
		n		5 (1, 15)		7 (3, 21)		7 (4, 18)		4 (1, 8)		5 (1, 10)		4 (2, 8)		4 (1, 7)		5 (1, 8)
		post_p		0.33 (0.12, 0.47)		0.33 (0.17, 0.47)		0.27 (0.12, 0.43)		0.35 (0.2, 0.46)		0.4 (0.19, 0.49)		0.39 (0.22, 0.48)		0.38 (0.22, 0.48)		0.4 (0.26, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.13 (0.079, 0.362)		0.152 (0.12, 0.276)		0.129 (0.084, 0.212)		0.185 (0.109, 0.491)		0.177 (0.101, 0.467)		0.157 (0.108, 1.154)		0.183 (0.108, 0.451)		0.163 (0.1, 0.654)