Setting description

Hormone therapies more effective in the TP53- & AR- biomarker signature

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.084, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 11.7, median = 8.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1.33, hr = 0.74 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.087, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 11.3, median = 8.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1.28, hr = 0.77 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.093, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 10.5, median = 7.6 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1.2, hr = 0.83 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.042, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 23.4, median = 16.9 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 2.67, hr = 0.36 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 29 2 1 0
TP53- & AR- 414 6 3 2
TP53+ 6 0 3 2
DRD+ 5 0 1 1
TEfus+ 8 3 2 3
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.058 0.004 0.002 0.000
TP53- & AR- 0.828 0.012 0.006 0.004
TP53+ 0.012 0.000 0.006 0.004
DRD+ 0.010 0.000 0.002 0.002
TEfus+ 0.016 0.006 0.004 0.006
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 4 4 2 1
TP53- & AR- 1 386 405 401
TP53+ 31 39 26 26
DRD+ 2 39 58 36
TEfus+ 6 61 43 40
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.008 0.008 0.004 0.002
TP53- & AR- 0.002 0.772 0.810 0.802
TP53+ 0.062 0.078 0.052 0.052
DRD+ 0.004 0.078 0.116 0.072
TEfus+ 0.012 0.122 0.086 0.080
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 50 18 19 25
TP53+ 4 11 10 7
DRD+ 0 0 0 0
TEfus+ 1 0 0 0
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.100 0.036 0.038 0.050
TP53+ 0.008 0.022 0.020 0.014
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.002 0.000 0.000 0.000


Errors & power

The overall error was 0.09.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.044             0.022             0.020             0.016 

The overall power was 0.828.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.828             0.000             0.000             0.000 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 29 2 1 0
futility 0 4 4 2 1
max_n 0 0 0 0 0
n 411 (348, 451) 159 (104, 256) 174 (126, 248) 163 (118, 247) 173 (124, 251)
n_unique 379 (321, 417) 146 (94, 242) 160 (115, 228) 150 (108, 230) 159 (113, 234)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 5 (4, 8) 11 (6, 24) 19 (9, 27) 22 (22, 22)
post_p NA (NA, NA) 0.97 (0.67, 1) 0.04 (0, 0.28) 0.04 (0, 0.3) 0.05 (0, 0.32)
rate 0.094 (0.087, 0.101) 0.077 (0.061, 0.09) 0.114 (0.102, 0.126) 0.114 (0.102, 0.126) 0.112 (0.101, 0.126)
TP53- & AR- graduation 0 414 6 3 2
futility 0 1 386 405 401
max_n 0 50 18 19 25
n 175 (109, 205) 35 (25, 151) 43 (25, 126) 41 (26, 130) 46 (26, 137)
n_unique 163 (100, 191) 33 (24, 141) 40 (23, 119) 38 (24, 119) 43 (24, 128)
time_trial 36 (36, 36) 11 (7, 36) 24 (14, 36) 23 (13, 36) 23 (14, 36)
time_stop NA (NA, NA) 9 (7, 22) 21 (13, 33) 20 (13, 32) 20 (13, 32)
post_p NA (NA, NA) 1 (0.97, 1) 0.02 (0, 0.14) 0.02 (0, 0.12) 0.02 (0, 0.13)
rate 0.075 (0.066, 0.084) 0.042 (0.032, 0.051) 0.115 (0.096, 0.144) 0.118 (0.097, 0.147) 0.114 (0.096, 0.145)
TP53+ graduation 0 6 0 3 2
futility 0 31 39 26 26
max_n 0 4 11 10 7
n 181 (159, 204) 83 (34, 120) 88 (52, 125) 85 (57, 123) 87 (55, 125)
n_unique 166 (145, 188) 76 (33, 111) 82 (48, 116) 79 (51, 114) 81 (49, 115)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 15 (10, 30) 19 (13, 27) 20 (13, 33) 20 (13, 34)
post_p NA (NA, NA) 0.5 (0.12, 0.9) 0.46 (0.1, 0.88) 0.46 (0.1, 0.86) 0.48 (0.11, 0.89)
rate 0.111 (0.102, 0.125) 0.112 (0.096, 0.133) 0.115 (0.099, 0.135) 0.114 (0.099, 0.134) 0.112 (0.097, 0.136)
DRD+ graduation 0 5 0 1 1
futility 0 2 39 58 36
max_n 0 0 0 0 0
n 108 (90, 124) 40 (23, 61) 50 (29, 73) 56 (37, 78) 58 (41, 80)
n_unique 99 (81, 114) 36 (20, 57) 45 (27, 67) 51 (34, 72) 54 (37, 74)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (29, 36) 36 (36, 36)
time_stop NA (NA, NA) 20 (19, 25) 26 (18, 33) 20 (13, 32) 21 (12, 31)
post_p NA (NA, NA) 0.63 (0.18, 0.97) 0.21 (0.02, 0.64) 0.2 (0.02, 0.68) 0.21 (0.03, 0.68)
rate 0.096 (0.083, 0.112) 0.09 (0.068, 0.123) 0.115 (0.094, 0.145) 0.114 (0.095, 0.14) 0.112 (0.095, 0.139)
TEfus+ graduation 0 8 3 2 3
futility 0 6 61 43 40
max_n 0 1 0 0 0
n 147 (126, 168) 58 (29, 88) 75 (43, 101) 70 (45, 95) 71 (48, 96)
n_unique 136 (116, 154) 53 (25, 81) 69 (39, 93) 63 (41, 87) 64 (43, 89)
time_trial 36 (36, 36) 36 (36, 36) 36 (30, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 20 (13, 27) 20 (10, 34) 24 (15, 32) 25 (13, 34)
post_p NA (NA, NA) 0.71 (0.26, 0.97) 0.24 (0.02, 0.66) 0.23 (0.03, 0.7) 0.25 (0.03, 0.73)
rate 0.1 (0.089, 0.113) 0.092 (0.071, 0.112) 0.114 (0.097, 0.137) 0.114 (0.096, 0.141) 0.112 (0.096, 0.139)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 441 396 409 403
futility 0 0 0 0 0
max_n 0 50 18 19 25
n 111 (72, 136) 27 (20, 105) 22 (9, 77) 18 (8, 82) 22 (9, 89)
n_unique 104 (66, 128) 26 (18, 99) 20 (8, 74) 17 (7, 78) 20 (8, 84)
post_p NA (NA, NA) 1 (0.91, 1) 0.08 (0, 0.33) 0.07 (0.01, 0.3) 0.07 (0, 0.3)
rate 0.075 (0.063, 0.087) 0.042 (0.032, 0.053) 0.115 (0.091, 0.172) 0.119 (0.091, 0.181) 0.117 (0.092, 0.166)
—+ graduation 0 442 404 412 408
futility 0 0 0 0 0
max_n 0 50 18 19 25
n 19 (11, 27) 4 (1, 15) 7 (3, 19) 6 (2, 17) 6 (2, 18)
n_unique 18 (10, 25) 4 (1, 14) 6 (3, 17) 6 (2, 15) 6 (2, 16)
post_p NA (NA, NA) 0.82 (0.5, 0.97) 0.28 (0.1, 0.57) 0.28 (0.1, 0.56) 0.3 (0.11, 0.57)
rate 0.075 (0.049, 0.11) 0.042 (0.019, 0.085) 0.124 (0.081, 0.238) 0.13 (0.078, 0.3) 0.124 (0.074, 0.291)
–+- graduation 0 70 42 30 28
futility 0 0 0 0 0
max_n 0 4 11 10 7
n 61 (49, 76) 24 (9, 56) 25 (7, 53) 24 (8, 55) 24 (7, 56)
n_unique 57 (44, 70) 23 (8, 53) 23 (7, 50) 23 (7, 51) 22 (7, 52)
post_p NA (NA, NA) 0.46 (0.11, 0.89) 0.43 (0.11, 0.84) 0.44 (0.12, 0.84) 0.42 (0.11, 0.87)
rate 0.112 (0.094, 0.134) 0.115 (0.088, 0.182) 0.12 (0.093, 0.212) 0.119 (0.091, 0.198) 0.121 (0.089, 0.21)
–++ graduation 0 82 94 67 63
futility 0 0 0 0 0
max_n 0 5 11 10 7
n 42 (32, 52) 14 (4, 36) 19 (8, 39) 17 (5, 34) 16 (5, 35)
n_unique 39 (28, 49) 13 (4, 33) 17 (7, 36) 15 (4, 33) 15 (4, 33)
post_p NA (NA, NA) 0.44 (0.15, 0.85) 0.44 (0.13, 0.84) 0.46 (0.13, 0.88) 0.44 (0.14, 0.87)
rate 0.113 (0.091, 0.142) 0.123 (0.085, 0.228) 0.122 (0.091, 0.185) 0.121 (0.085, 0.236) 0.121 (0.085, 0.25)
-+– graduation 0 441 402 414 408
futility 0 0 0 0 0
max_n 0 50 17 19 25
n 20 (11, 27) 2 (0, 12) 7 (2, 18) 8 (3, 18) 7 (3, 19)
n_unique 18 (10, 25) 2 (0, 11) 6 (2, 17) 7 (3, 17) 7 (3, 17)
post_p NA (NA, NA) 0.77 (0.43, 0.96) 0.28 (0.12, 0.6) 0.27 (0.1, 0.6) 0.27 (0.11, 0.59)
rate 0.075 (0.053, 0.109) 0.045 (0.012, 0.117) 0.125 (0.078, 0.283) 0.123 (0.079, 0.257) 0.122 (0.081, 0.234)
-+-+ graduation 0 442 408 417 413
futility 0 0 0 0 0
max_n 0 50 17 19 25
n 20 (11, 27) 2 (0, 13) 6 (2, 18) 7 (3, 18) 7 (3, 19)
n_unique 18 (10, 25) 2 (0, 13) 6 (2, 17) 7 (3, 17) 7 (3, 18)
post_p NA (NA, NA) 0.77 (0.44, 0.96) 0.29 (0.11, 0.58) 0.26 (0.1, 0.55) 0.27 (0.1, 0.58)
rate 0.075 (0.051, 0.11) 0.044 (0.013, 0.12) 0.124 (0.08, 0.286) 0.128 (0.078, 0.271) 0.12 (0.079, 0.236)
-++- graduation 0 77 73 82 55
futility 0 0 0 0 0
max_n 0 4 11 10 7
n 11 (7, 16) 4 (1, 10) 5 (1, 10) 5 (2, 12) 6 (2, 12)
n_unique 10 (6, 15) 4 (1, 9) 4 (1, 9) 5 (2, 11) 6 (2, 11)
post_p NA (NA, NA) 0.48 (0.24, 0.79) 0.44 (0.22, 0.77) 0.46 (0.22, 0.78) 0.51 (0.22, 0.82)
rate 0.116 (0.075, 0.186) 0.125 (0.068, 0.363) 0.142 (0.068, 0.39) 0.127 (0.072, 0.327) 0.118 (0.071, 0.283)
-+++ graduation 0 89 120 115 86
futility 0 0 0 0 0
max_n 0 5 11 10 7
n 11 (7, 16) 4 (1, 10) 5 (1, 10) 6 (2, 12) 6 (2, 12)
n_unique 10 (6, 15) 4 (1, 9) 4 (1, 10) 5 (2, 11) 6 (2, 11)
post_p NA (NA, NA) 0.45 (0.24, 0.78) 0.44 (0.24, 0.79) 0.45 (0.21, 0.81) 0.45 (0.21, 0.81)
rate 0.116 (0.075, 0.182) 0.134 (0.07, 0.363) 0.132 (0.067, 0.408) 0.126 (0.073, 0.308) 0.129 (0.071, 0.325)
+— graduation 0 33 6 3 1
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 19 (13, 26) 8 (3, 18) 11 (5, 20) 8 (3, 17) 8 (3, 18)
n_unique 17 (12, 23) 7 (2, 16) 10 (4, 18) 8 (3, 15) 8 (3, 16)
post_p NA (NA, NA) 0.45 (0.19, 0.79) 0.49 (0.19, 0.84) 0.46 (0.18, 0.86) 0.48 (0.18, 0.85)
rate 0.112 (0.084, 0.164) 0.125 (0.08, 0.268) 0.12 (0.081, 0.222) 0.119 (0.075, 0.337) 0.125 (0.07, 0.311)
+–+ graduation 0 47 68 48 44
futility 0 0 0 0 0
max_n 0 1 0 0 0
n 16 (10, 21) 7 (2, 15) 8 (4, 16) 6 (2, 13) 7 (2, 15)
n_unique 14 (9, 20) 6 (2, 14) 8 (3, 16) 6 (2, 13) 6 (2, 14)
post_p NA (NA, NA) 0.48 (0.21, 0.85) 0.48 (0.18, 0.82) 0.45 (0.2, 0.8) 0.44 (0.21, 0.82)
rate 0.116 (0.075, 0.17) 0.121 (0.071, 0.299) 0.123 (0.081, 0.254) 0.129 (0.067, 0.321) 0.124 (0.072, 0.317)
+-+- graduation 0 70 42 30 28
futility 0 0 0 0 0
max_n 0 4 11 10 7
n 15 (10, 21) 6 (2, 14) 8 (3, 15) 7 (3, 14) 7 (2, 15)
n_unique 14 (9, 20) 5 (2, 13) 7 (2, 14) 6 (3, 13) 6 (2, 14)
post_p NA (NA, NA) 0.47 (0.2, 0.83) 0.47 (0.2, 0.8) 0.45 (0.2, 0.83) 0.47 (0.23, 0.82)
rate 0.116 (0.081, 0.165) 0.122 (0.072, 0.323) 0.119 (0.076, 0.267) 0.125 (0.074, 0.273) 0.127 (0.07, 0.292)
+-++ graduation 0 82 94 67 63
futility 0 0 0 0 0
max_n 0 5 11 10 7
n 16 (10, 22) 6 (2, 14) 8 (3, 16) 7 (2, 15) 7 (2, 16)
n_unique 14 (9, 20) 5 (1, 13) 7 (2, 15) 6 (2, 13) 6 (2, 14)
post_p NA (NA, NA) 0.45 (0.19, 0.84) 0.48 (0.2, 0.82) 0.42 (0.19, 0.83) 0.48 (0.21, 0.84)
rate 0.116 (0.081, 0.169) 0.128 (0.073, 0.358) 0.122 (0.076, 0.272) 0.135 (0.076, 0.335) 0.12 (0.073, 0.348)
++– graduation 0 40 44 60 37
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 11 (7, 16) 5 (1, 10) 5 (2, 11) 6 (2, 11) 6 (3, 11)
n_unique 10 (6, 15) 4 (1, 9) 5 (2, 10) 5 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.45 (0.24, 0.82) 0.46 (0.23, 0.81) 0.46 (0.21, 0.79) 0.47 (0.21, 0.83)
rate 0.114 (0.077, 0.187) 0.127 (0.066, 0.316) 0.124 (0.067, 0.288) 0.125 (0.073, 0.306) 0.123 (0.07, 0.28)
++-+ graduation 0 54 99 97 72
futility 0 0 0 0 0
max_n 0 1 0 0 0
n 11 (6, 16) 5 (1, 10) 5 (2, 11) 6 (2, 12) 5 (2, 13)
n_unique 10 (6, 15) 4 (1, 10) 4 (1, 10) 5 (2, 11) 5 (2, 12)
post_p NA (NA, NA) 0.47 (0.24, 0.78) 0.47 (0.23, 0.8) 0.46 (0.21, 0.8) 0.47 (0.21, 0.8)
rate 0.114 (0.074, 0.183) 0.127 (0.068, 0.297) 0.13 (0.066, 0.37) 0.131 (0.075, 0.338) 0.128 (0.073, 0.309)
+++- graduation 0 77 73 82 55
futility 0 0 0 0 0
max_n 0 4 11 10 7
n 11 (6, 16) 5 (1, 11) 5 (2, 11) 6 (2, 12) 6 (2, 12)
n_unique 10 (6, 15) 4 (1, 10) 5 (1, 10) 6 (2, 11) 5 (2, 12)
post_p NA (NA, NA) 0.47 (0.22, 0.83) 0.44 (0.22, 0.81) 0.45 (0.21, 0.77) 0.46 (0.2, 0.79)
rate 0.113 (0.071, 0.18) 0.128 (0.065, 0.348) 0.134 (0.065, 0.349) 0.129 (0.076, 0.329) 0.13 (0.072, 0.327)
++++ graduation 0 89 120 115 86
futility 0 0 0 0 0
max_n 0 5 11 10 7
n 11 (7, 17) 5 (1, 11) 5 (1, 11) 6 (2, 12) 6 (2, 11)
n_unique 10 (6, 15) 4 (1, 10) 4 (1, 10) 6 (2, 11) 5 (2, 11)
post_p NA (NA, NA) 0.47 (0.23, 0.83) 0.44 (0.23, 0.79) 0.48 (0.23, 0.81) 0.46 (0.22, 0.8)
rate 0.114 (0.075, 0.186) 0.125 (0.063, 0.348) 0.13 (0.067, 0.383) 0.124 (0.071, 0.271) 0.124 (0.072, 0.306)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 29 2 1
time_stop 5 (4, 8) 6 (5, 7) 6 (6, 6)
n_trt 34 (27, 49) 30 (26, 35) 31 (31, 31)
n_control 51 (43, 77) 66 (56, 77) 57 (57, 57)
post_p 0.95 (0.87, 0.99) 0.94 (0.9, 0.98) 0.9 (0.9, 0.9)
order 1 (1, 1.2) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 414 6 3 2
time_stop 10 (7, 22) 12 (10, 14) 12 (11, 13) 12 (11, 14)
n_trt 34 (26, 90) 29 (27, 37) 28 (26, 30) 28 (28, 29)
n_control 41 (27, 101) 48 (46, 56) 36 (35, 41) 64 (53, 76)
post_p 0.95 (0.88, 1) 0.91 (0.89, 0.95) 0.88 (0.86, 0.92) 0.92 (0.87, 0.98)
order 1 (1, 1) 1.5 (1, 2) 1 (1, 1.8) 2 (2, 2)
TP53+ count 6 3 2
time_stop 10 (10, 14) 17 (12, 31) 16 (14, 18)
n_trt 36 (30, 48) 44 (34, 108) 34 (30, 38)
n_control 48 (43, 62) 82 (47, 148) 79 (70, 88)
post_p 0.97 (0.93, 0.98) 0.99 (0.99, 1) 0.94 (0.93, 0.95)
order 2 (1, 2) 2 (1.2, 2) 2 (2, 2)
DRD+ count 5 1 1
time_stop 20 (19, 22) 15 (15, 15) 11 (11, 11)
n_trt 28 (27, 37) 25 (25, 25) 25 (25, 25)
n_control 56 (49, 71) 42 (42, 42) 26 (26, 26)
post_p 0.98 (0.92, 0.99) 1 (1, 1) 0.94 (0.94, 0.94)
order 2 (1.4, 2) 2 (2, 2) 2 (2, 2)
TEfus+ count 8 3 2 3
time_stop 20 (16, 25) 8 (6, 13) 12 (11, 12) 11 (11, 14)
n_trt 36 (26, 50) 26 (25, 33) 28 (28, 28) 27 (26, 28)
n_control 78 (60, 98) 30 (26, 44) 37 (31, 43) 45 (39, 48)
post_p 0.98 (0.93, 1) 0.96 (0.94, 0.98) 0.99 (0.98, 0.99) 0.93 (0.89, 0.98)
order 2 (1.7, 2.3) 2 (1.2, 2.8) 1.5 (1.1, 1.9) 2 (2, 2)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 4 4 2 1
time_stop 4 (3, 4) 16 (9, 27) 24 (20, 28) 22 (22, 22)
n_trt 28 (27, 29) 72 (47, 103) 83 (71, 95) 84 (84, 84)
n_control 38 (33, 42) 186 (95, 292) 250 (234, 266) 249 (249, 249)
post_p 0.25 (0.19, 0.27) 0.02 (0, 0.03) 0.01 (0, 0.02) 0.01 (0.01, 0.01)
order 1 (1, 1) 3 (1.3, 5.4) 4.5 (3.3, 5.7) 3 (3, 3)
TP53- & AR- count 1 386 405 401
time_stop 9 (9, 9) 21 (13, 33) 20 (13, 32) 20 (13, 32)
n_trt 25 (25, 25) 37 (25, 100) 35 (25, 96) 39 (25, 94)
n_control 26 (26, 26) 100 (57, 170) 100 (56, 165) 96 (54, 164)
post_p 0.26 (0.26, 0.26) 0.06 (0, 0.2) 0.05 (0, 0.19) 0.06 (0, 0.19)
order 1 (1, 1) 2 (1, 4) 2 (1, 4) 2 (1, 4)
TP53+ count 31 39 26 26
time_stop 16 (10, 30) 19 (13, 27) 20 (13, 32) 22 (13, 34)
n_trt 36 (25, 70) 41 (27, 68) 40 (25, 62) 43 (26, 58)
n_control 79 (37, 147) 90 (51, 128) 87 (52, 152) 104 (62, 170)
post_p 0.05 (0.02, 0.15) 0.08 (0.04, 0.22) 0.06 (0.01, 0.16) 0.04 (0, 0.14)
order 1 (1, 4) 2 (1, 4) 2.5 (1, 5) 2 (1, 5)
DRD+ count 2 39 58 36
time_stop 24 (21, 28) 26 (18, 33) 20 (13, 32) 21 (12, 31)
n_trt 28 (26, 30) 29 (25, 46) 36 (26, 50) 32 (25, 63)
n_control 78 (61, 95) 75 (47, 107) 58 (30, 95) 59 (28, 99)
post_p 0.04 (0.04, 0.04) 0.04 (0, 0.16) 0.04 (0, 0.15) 0.04 (0, 0.19)
order 3 (2.2, 3.8) 3 (2, 4.2) 3 (1, 4.3) 3 (1, 4.5)
TEfus+ count 6 61 43 40
time_stop 20 (12, 26) 21 (11, 34) 24 (16, 33) 26 (15, 34)
n_trt 30 (25, 37) 41 (26, 70) 39 (26, 58) 47 (28, 78)
n_control 90 (42, 114) 82 (40, 129) 96 (60, 131) 108 (53, 137)
post_p 0.06 (0.02, 0.11) 0.04 (0, 0.15) 0.04 (0.01, 0.14) 0.05 (0.01, 0.12)
order 2 (1, 3.5) 3 (1, 5) 3 (1.2, 5) 4 (2, 6)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29 29
time 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8) 5 (4, 8)
n 17 (11, 25) 2 (1, 5) 8 (4, 11) 3 (0, 5) 0 (0, 1) 0 (0, 1) 0 (0, 1) 0 (0, 1) 1 (0, 3) 1 (0, 2) 0 (0, 3) 0 (0, 2) 0 (0, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1)
post_p 0.66 (0.56, 0.9) 0.55 (0.51, 0.64) 0.59 (0.52, 0.71) 0.55 (0.52, 0.66) 0.57 (0.54, 0.59) 0.53 (0.51, 0.6) 0.58 (0.53, 0.72) 0.52 (0.5, 0.54) 0.54 (0.52, 0.58) 0.54 (0.52, 0.58) 0.56 (0.53, 0.57) 0.52 (0.51, 0.6) 0.54 (0.52, 0.58) 0.52 (0.52, 0.6) 0.54 (0.53, 0.62) 0.55 (0.53, 0.57)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.027 (0.005, 0.061) 0 (0, 0.021) 0.08 (0, 0.113) 0 (0, 0.104) 0 (0, 0.027) 0 (0, 0) 0 (0, 0.137) 0 (0, 1.004) 0 (0, 0.083) 0 (0, 0.271) 0 (0, 0.064) 0 (0, 0) 0 (0, 0.01) 0 (0, 0.05) 0 (0, 0) 0 (0, 0.313)
Taxel_therapies count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7) 6 (5, 7)
n 3 (1, 5) 2 (0, 3) 4 (3, 4) 6 (5, 7) 0 (0, 1) 0 (0, 0) 0 (0, 1) 1 (0, 2) 3 (2, 4) 4 (2, 6) 2 (2, 2) 4 (4, 5) 0 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 1)
post_p 0.62 (0.62, 0.62) 0.58 (0.58, 0.58) 0.56 (0.55, 0.57) 0.55 (0.53, 0.58) 0.55 (0.55, 0.55) NA (NA, NA) 0.55 (0.55, 0.55) 0.52 (0.52, 0.52) 0.54 (0.53, 0.55) 0.6 (0.55, 0.65) 0.57 (0.53, 0.61) 0.58 (0.58, 0.58) 0.54 (0.54, 0.54) NA (NA, NA) 0.52 (0.52, 0.52) 0.53 (0.53, 0.53)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0 (0, 0) 0 (0, 0) 0.055 (0.011, 0.099) 0.048 (0.01, 0.087) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.035 (0.007, 0.063) 0.019 (0.004, 0.034) 0 (0, 0) 0.065 (0.013, 0.117) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6) 6 (6, 6)
n 8 (8, 8) 0 (0, 0) 5 (5, 5) 0 (0, 0) 1 (1, 1) 6 (6, 6) 2 (2, 2) 1 (1, 1) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 2 (2, 2) 1 (1, 1) 2 (2, 2) 1 (1, 1)
post_p 0.67 (0.67, 0.67) NA (NA, NA) 0.56 (0.56, 0.56) NA (NA, NA) NA (NA, NA) 0.56 (0.56, 0.56) 0.52 (0.52, 0.52) 0.57 (0.57, 0.57) 0.51 (0.51, 0.51) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) 0.56 (0.56, 0.56) 0.57 (0.57, 0.57)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) NA (NA, NA) 0.06 (0.06, 0.06) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.308 (0.308, 0.308) 0.922 (0.922, 0.922) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53- & AR- Hormone_therapies count 414 414 414 414
time 10 (7, 22) 10 (7, 22) 10 (7, 22) 10 (7, 22)
n 26 (20, 64) 4 (1, 11) 2 (0, 8) 2 (0, 8)
post_p 0.87 (0.74, 1) 0.6 (0.52, 0.8) 0.58 (0.51, 0.86) 0.58 (0.51, 0.84)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.037 (0.016, 0.056) 0.017 (0, 0.074) 0 (0, 0.073) 0 (0, 0.07)
Taxel_therapies count 6 6 6 6
time 12 (10, 14) 12 (10, 14) 12 (10, 14) 12 (10, 14)
n 23 (18, 28) 4 (1, 5) 2 (0, 6) 2 (0, 4)
post_p 0.76 (0.75, 0.91) 0.61 (0.52, 0.75) 0.61 (0.56, 0.7) 0.56 (0.53, 0.58)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.053 (0.031, 0.076) 0.014 (0, 0.045) 0 (0, 0.029) 0 (0, 0.081)
Carboplatin count 3 3 3 3
time 12 (11, 13) 12 (11, 13) 12 (11, 13) 12 (11, 13)
n 16 (14, 18) 4 (3, 5) 5 (3, 5) 3 (3, 5)
post_p 0.84 (0.84, 0.84) 0.61 (0.54, 0.61) 0.61 (0.57, 0.66) 0.55 (0.52, 0.68)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.033 (0.03, 0.035) 0.055 (0.011, 0.088) 0.067 (0.037, 0.072) 0.083 (0.036, 0.1)
Niraparib count 2 2 2 2
time 12 (11, 14) 12 (11, 14) 12 (11, 14) 12 (11, 14)
n 10 (5, 16) 4 (4, 5) 6 (4, 8) 8 (6, 10)
post_p 0.66 (0.62, 0.71) 0.66 (0.65, 0.67) 0.65 (0.56, 0.75) 0.64 (0.57, 0.7)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.053 (0.039, 0.067) 0 (0, 0) 0.054 (0.011, 0.098) 0.04 (0.035, 0.044)
TP53+ Hormone_therapies count 6 6 6 6 6 6 6 6
time 10 (10, 14) 10 (10, 14) 10 (10, 14) 10 (10, 14) 10 (10, 14) 10 (10, 14) 10 (10, 14) 10 (10, 14)
n 18 (13, 20) 6 (4, 10) 2 (2, 4) 2 (0, 4) 3 (1, 4) 2 (0, 6) 2 (0, 5) 2 (0, 5)
post_p 0.79 (0.71, 0.86) 0.72 (0.63, 0.89) 0.59 (0.54, 0.68) 0.63 (0.55, 0.78) 0.55 (0.52, 0.6) 0.58 (0.52, 0.8) 0.57 (0.54, 0.58) 0.6 (0.56, 0.8)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.076 (0.049, 0.09) 0.048 (0.038, 0.093) 0 (0, 0.087) 0.013 (0, 0.066) 0.033 (0, 0.125) 0.051 (0, 0.095) 0.125 (0, 0.192) 0.088 (0.018, 0.09)
Carboplatin count 3 3 3 3 3 3 3 3
time 17 (12, 31) 17 (12, 31) 17 (12, 31) 17 (12, 31) 17 (12, 31) 17 (12, 31) 17 (12, 31) 17 (12, 31)
n 16 (10, 38) 7 (5, 25) 4 (4, 5) 5 (3, 5) 4 (3, 9) 1 (1, 19) 4 (2, 7) 4 (2, 4)
post_p 0.8 (0.79, 0.82) 0.82 (0.79, 0.83) 0.54 (0.53, 0.6) 0.58 (0.55, 0.79) 0.65 (0.64, 0.7) 0.62 (0.55, 0.9) 0.79 (0.59, 0.82) 0.62 (0.54, 0.66)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.083 (0.074, 0.092) 0.083 (0.017, 0.097) 0.128 (0.098, 0.19) 0.069 (0.044, 0.104) 0.033 (0.007, 0.093) 0 (0, 0.066) 0.044 (0.009, 0.05) 0.105 (0.021, 0.132)
Niraparib count 2 2 2 2 2 2 2 2
time 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18) 16 (14, 18)
n 10 (8, 11) 6 (6, 6) 4 (3, 6) 2 (2, 3) 4 (2, 6) 1 (0, 2) 2 (1, 4) 4 (4, 5)
post_p 0.8 (0.75, 0.85) 0.75 (0.72, 0.78) 0.65 (0.59, 0.71) 0.54 (0.53, 0.54) 0.67 (0.56, 0.78) 0.56 (0.56, 0.56) 0.53 (0.51, 0.56) 0.71 (0.68, 0.73)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.056 (0.049, 0.063) 0.031 (0.006, 0.056) 0.088 (0.065, 0.112) 0.133 (0.12, 0.147) 0.035 (0.007, 0.064) 0.117 (0.117, 0.117) 0.03 (0.006, 0.054) 0.097 (0.056, 0.138)
DRD+ Hormone_therapies count 5 5 5 5 5 5 5 5
time 20 (19, 22) 20 (19, 22) 20 (19, 22) 20 (19, 22) 20 (19, 22) 20 (19, 22) 20 (19, 22) 20 (19, 22)
n 1 (0, 3) 4 (2, 7) 4 (3, 9) 3 (1, 6) 3 (1, 6) 4 (1, 8) 5 (4, 7) 3 (1, 6)
post_p 0.52 (0.51, 0.71) 0.75 (0.58, 0.86) 0.79 (0.72, 0.83) 0.66 (0.53, 0.74) 0.59 (0.53, 0.72) 0.58 (0.56, 0.86) 0.65 (0.64, 0.78) 0.66 (0.55, 0.85)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.056 (0.011, 0.088) 0.024 (0.009, 0.083) 0.033 (0.012, 0.08) 0.064 (0.012, 0.108) 0.071 (0.025, 0.092) 0 (0, 0.068) 0.057 (0.055, 0.072) 0.022 (0, 0.09)
Carboplatin count 1 1 1 1 1 1 1 1
time 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15) 15 (15, 15)
n 5 (5, 5) 7 (7, 7) 0 (0, 0) 4 (4, 4) 5 (5, 5) 2 (2, 2) 1 (1, 1) 1 (1, 1)
post_p 0.62 (0.62, 0.62) 0.85 (0.85, 0.85) NA (NA, NA) 0.82 (0.82, 0.82) 0.8 (0.8, 0.8) 0.6 (0.6, 0.6) 0.6 (0.6, 0.6) 0.57 (0.57, 0.57)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.072 (0.072, 0.072) 0.022 (0.022, 0.022) NA (NA, NA) 0.035 (0.035, 0.035) 0.025 (0.025, 0.025) 0.115 (0.115, 0.115) 0 (0, 0) 0 (0, 0)
Niraparib count 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 2 (2, 2) 3 (3, 3) 2 (2, 2) 3 (3, 3) 5 (5, 5) 3 (3, 3) 3 (3, 3) 4 (4, 4)
post_p 0.61 (0.61, 0.61) 0.59 (0.59, 0.59) 0.55 (0.55, 0.55) 0.52 (0.52, 0.52) 0.58 (0.58, 0.58) 0.56 (0.56, 0.56) 0.58 (0.58, 0.58) 0.66 (0.66, 0.66)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.128 (0.128, 0.128) 0.036 (0.036, 0.036) 0 (0, 0) 0 (0, 0) 0.094 (0.094, 0.094)
TEfus+ Hormone_therapies count 8 8 8 8 8 8 8 8
time 20 (16, 25) 20 (16, 25) 20 (16, 25) 20 (16, 25) 20 (16, 25) 20 (16, 25) 20 (16, 25) 20 (16, 25)
n 4 (2, 8) 12 (8, 15) 3 (0, 5) 4 (1, 5) 4 (2, 6) 4 (1, 11) 4 (1, 8) 4 (1, 5)
post_p 0.77 (0.6, 0.93) 0.82 (0.71, 0.88) 0.81 (0.67, 0.91) 0.62 (0.5, 0.75) 0.6 (0.53, 0.72) 0.58 (0.51, 0.8) 0.71 (0.57, 0.79) 0.56 (0.53, 0.78)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.035 (0, 0.07) 0.083 (0.05, 0.088) 0.007 (0, 0.041) 0.062 (0.037, 0.111) 0.089 (0.06, 0.105) 0.088 (0, 0.135) 0 (0, 0.094) 0.079 (0, 0.095)
Taxel_therapies count 3 3 3 3 3 3 3 3
time 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13) 8 (6, 13)
n 1 (0, 3) 14 (11, 19) 1 (0, 3) 1 (0, 3) 4 (4, 4) 3 (3, 5) 0 (0, 2) 1 (0, 2)
post_p 0.6 (0.52, 0.67) 0.8 (0.77, 0.83) 0.53 (0.53, 0.53) 0.6 (0.57, 0.63) 0.54 (0.51, 0.65) 0.55 (0.52, 0.58) 0.64 (0.64, 0.64) 0.59 (0.59, 0.59)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.038 (0.008, 0.068) 0.051 (0.028, 0.082) 0.072 (0.014, 0.13) 0 (0, 0) 0 (0, 0.037) 0.065 (0.039, 0.079) 0 (0, 0) 0 (0, 0)
Carboplatin count 2 2 2 2 2 2 2 2
time 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12) 12 (11, 12)
n 4 (4, 5) 8 (8, 9) 7 (5, 9) 2 (2, 2) 2 (0, 3) 0 (0, 0) 3 (3, 3) 2 (0, 3)
post_p 0.62 (0.6, 0.64) 0.79 (0.75, 0.83) 0.71 (0.63, 0.78) 0.61 (0.6, 0.61) 0.6 (0.6, 0.6) NA (NA, NA) 0.54 (0.53, 0.55) 0.68 (0.68, 0.68)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.024 (0.005, 0.043) 0.043 (0.037, 0.048) 0.035 (0.026, 0.043) 0.027 (0.005, 0.048) 0 (0, 0) NA (NA, NA) 0.057 (0.049, 0.065) 0 (0, 0)
Niraparib count 3 3 3 3 3 3 3 3
time 11 (11, 14) 11 (11, 14) 11 (11, 14) 11 (11, 14) 11 (11, 14) 11 (11, 14) 11 (11, 14) 11 (11, 14)
n 1 (1, 6) 4 (3, 6) 5 (5, 5) 2 (2, 6) 3 (1, 4) 1 (1, 3) 3 (3, 5) 3 (2, 5)
post_p 0.61 (0.54, 0.8) 0.64 (0.6, 0.74) 0.54 (0.51, 0.62) 0.73 (0.66, 0.82) 0.68 (0.6, 0.75) 0.57 (0.56, 0.58) 0.65 (0.56, 0.72) 0.56 (0.52, 0.66)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0.049) 0.043 (0.009, 0.097) 0.08 (0.016, 0.101) 0 (0, 0.099) 0 (0, 0) 0 (0, 0) 0.062 (0.058, 0.105) 0.071 (0.014, 0.082)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4) 4 (3, 4)
n 14 (12, 17) 3 (1, 5) 6 (5, 6) 3 (2, 3) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0) 2 (1, 2) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 1)
post_p 0.44 (0.37, 0.48) 0.42 (0.4, 0.43) 0.44 (0.39, 0.47) 0.42 (0.38, 0.47) NA (NA, NA) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) 0.44 (0.43, 0.47) NA (NA, NA) 0.41 (0.41, 0.41) 0.48 (0.48, 0.48) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.47 (0.47, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.076 (0.05, 0.094) 0.056 (0, 0.256) 0.232 (0.205, 0.25) 0.208 (0.054, 1.418) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA) 0.095 (0, 0.588) NA (NA, NA) 1.414 (1.414, 1.414) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0 (0, 0)
Taxel_therapies count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27) 16 (9, 27)
n 12 (6, 32) 4 (2, 6) 6 (3, 9) 8 (7, 12) 4 (0, 10) 4 (1, 6) 2 (1, 3) 0 (0, 1) 8 (6, 12) 6 (5, 7) 6 (4, 7) 2 (1, 4) 2 (2, 3) 0 (0, 2) 1 (0, 2) 2 (0, 3)
post_p 0.11 (0.02, 0.16) 0.35 (0.27, 0.36) 0.33 (0.2, 0.43) 0.44 (0.44, 0.46) 0.37 (0.32, 0.45) 0.42 (0.3, 0.48) 0.33 (0.26, 0.36) 0.4 (0.4, 0.4) 0.4 (0.32, 0.43) 0.45 (0.21, 0.49) 0.4 (0.19, 0.44) 0.36 (0.35, 0.45) 0.41 (0.29, 0.48) 0.4 (0.36, 0.44) 0.4 (0.35, 0.44) 0.28 (0.21, 0.44)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.16 (0.126, 0.387) 0.151 (0.118, 0.547) 0.18 (0.168, 0.243) 0.102 (0.099, 0.131) 0.134 (0.116, 0.293) 0.095 (0.06, 0.232) 0.312 (0.2, 0.332) 0.467 (0.467, 0.467) 0.13 (0.107, 0.169) 0.127 (0.094, 0.504) 0.109 (0.094, 0.534) 0.162 (0.111, 0.269) 0.238 (0.196, 0.313) 0.469 (0.267, 0.672) 0.31 (0.281, 0.339) 0.514 (0.151, 1.106)
Carboplatin count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
time 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28) 24 (20, 28)
n 26 (13, 38) 7 (6, 8) 10 (8, 13) 2 (1, 4) 10 (8, 12) 2 (1, 2) 2 (1, 3) 2 (2, 3) 4 (4, 4) 2 (2, 3) 2 (1, 4) 2 (1, 4) 2 (2, 3) 2 (2, 3) 2 (1, 3) 3 (3, 3)
post_p 0.18 (0.09, 0.27) 0.14 (0.1, 0.18) 0.4 (0.35, 0.46) 0.31 (0.24, 0.39) 0.27 (0.15, 0.39) 0.3 (0.29, 0.31) 0.33 (0.27, 0.38) 0.4 (0.35, 0.44) 0.35 (0.3, 0.39) 0.35 (0.3, 0.39) 0.22 (0.22, 0.22) 0.28 (0.28, 0.28) 0.41 (0.34, 0.48) 0.32 (0.31, 0.33) 0.37 (0.3, 0.45) 0.4 (0.32, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.13 (0.107, 0.152) 0.222 (0.147, 0.298) 0.122 (0.118, 0.127) 0.291 (0.235, 0.348) 0.14 (0.126, 0.155) 0.611 (0.263, 0.958) 0.321 (0.238, 0.405) 0.171 (0.082, 0.259) 0.193 (0.179, 0.208) 0.391 (0.208, 0.574) 0.25 (0.25, 0.25) 0.175 (0.175, 0.175) 0.186 (0.109, 0.262) 0.32 (0.303, 0.338) 0.285 (0.247, 0.322) 0.162 (0.108, 0.216)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22) 22 (22, 22)
n 25 (25, 25) 1 (1, 1) 12 (12, 12) 1 (1, 1) 11 (11, 11) 9 (9, 9) 1 (1, 1) 4 (4, 4) 2 (2, 2) 3 (3, 3) 3 (3, 3) 1 (1, 1) 5 (5, 5) 3 (3, 3) 2 (2, 2) 1 (1, 1)
post_p 0.24 (0.24, 0.24) 0.36 (0.36, 0.36) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.45 (0.45, 0.45) 0.35 (0.35, 0.35) 0.42 (0.42, 0.42) 0.35 (0.35, 0.35) 0.36 (0.36, 0.36) 0.39 (0.39, 0.39) 0.29 (0.29, 0.29) 0.42 (0.42, 0.42) 0.36 (0.36, 0.36) 0.49 (0.49, 0.49) 0.23 (0.23, 0.23) 0.38 (0.38, 0.38)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.107 (0.107, 0.107) 30.678 (30.678, 30.678) 0.145 (0.145, 0.145) 1.506 (1.506, 1.506) 0.082 (0.082, 0.082) 0.139 (0.139, 0.139) 0.221 (0.221, 0.221) 0.153 (0.153, 0.153) 0.575 (0.575, 0.575) 0.175 (0.175, 0.175) 0.268 (0.268, 0.268) 0.287 (0.287, 0.287) 0.112 (0.112, 0.112) 0.166 (0.166, 0.166) 0.326 (0.326, 0.326) 0.64 (0.64, 0.64)
TP53- & AR- Hormone_therapies count 1 1 1 1
time 9 (9, 9) 9 (9, 9) 9 (9, 9) 9 (9, 9)
n 18 (18, 18) 3 (3, 3) 1 (1, 1) 3 (3, 3)
post_p 0.45 (0.45, 0.45) 0.45 (0.45, 0.45) 0.38 (0.38, 0.38) 0.47 (0.47, 0.47)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.087 (0.087, 0.087) 0.063 (0.063, 0.063) 0.214 (0.214, 0.214) 0.153 (0.153, 0.153)
Taxel_therapies count 386 386 386 386
time 21 (13, 33) 21 (13, 33) 21 (13, 33) 21 (13, 33)
n 20 (9, 59) 6 (3, 15) 6 (2, 15) 6 (2, 16)
post_p 0.19 (0.03, 0.43) 0.34 (0.15, 0.48) 0.38 (0.17, 0.48) 0.38 (0.17, 0.48)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.114 (0.088, 0.176) 0.131 (0.082, 0.258) 0.134 (0.086, 0.298) 0.131 (0.084, 0.325)
Carboplatin count 405 405 405 405
time 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32)
n 17 (8, 59) 6 (2, 14) 7 (3, 15) 7 (3, 15)
post_p 0.19 (0.02, 0.45) 0.38 (0.16, 0.48) 0.34 (0.12, 0.48) 0.34 (0.15, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.118 (0.09, 0.198) 0.137 (0.083, 0.328) 0.127 (0.085, 0.277) 0.128 (0.088, 0.287)
Niraparib count 401 401 401 401
time 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32)
n 19 (9, 63) 5 (2, 14) 7 (3, 15) 7 (3, 16)
post_p 0.21 (0.03, 0.43) 0.38 (0.2, 0.48) 0.36 (0.18, 0.48) 0.37 (0.17, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.116 (0.087, 0.175) 0.128 (0.081, 0.344) 0.126 (0.078, 0.247) 0.122 (0.082, 0.25)
TP53+ Hormone_therapies count 31 31 31 31 31 31 31 31
time 16 (10, 30) 16 (10, 30) 16 (10, 30) 16 (10, 30) 16 (10, 30) 16 (10, 30) 16 (10, 30) 16 (10, 30)
n 13 (8, 26) 7 (4, 16) 2 (0, 5) 2 (1, 5) 4 (1, 6) 4 (0, 5) 2 (0, 5) 2 (1, 7)
post_p 0.24 (0.11, 0.45) 0.34 (0.18, 0.47) 0.43 (0.32, 0.48) 0.38 (0.25, 0.49) 0.4 (0.29, 0.48) 0.4 (0.15, 0.45) 0.4 (0.19, 0.46) 0.43 (0.32, 0.48)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.14 (0.108, 0.182) 0.148 (0.107, 0.293) 0.167 (0.109, 1.08) 0.194 (0.08, 1.276) 0.154 (0.108, 0.415) 0.163 (0.093, 0.385) 0.268 (0.114, 0.574) 0.165 (0.058, 0.871)
Taxel_therapies count 39 39 39 39 39 39 39 39
time 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27) 19 (13, 27)
n 10 (5, 34) 10 (6, 17) 2 (0, 4) 2 (0, 5) 5 (2, 7) 3 (2, 8) 2 (0, 5) 2 (0, 5)
post_p 0.34 (0.15, 0.47) 0.36 (0.14, 0.45) 0.37 (0.22, 0.47) 0.4 (0.28, 0.49) 0.4 (0.23, 0.47) 0.38 (0.27, 0.47) 0.41 (0.27, 0.49) 0.42 (0.23, 0.49)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.136 (0.098, 0.281) 0.13 (0.104, 0.205) 0.234 (0.109, 0.456) 0.237 (0.096, 0.897) 0.169 (0.088, 0.335) 0.162 (0.102, 0.517) 0.194 (0.101, 0.792) 0.256 (0.098, 0.611)
Carboplatin count 26 26 26 26 26 26 26 26
time 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32)
n 13 (6, 20) 5 (2, 16) 3 (1, 5) 3 (2, 6) 4 (2, 11) 2 (1, 5) 4 (0, 9) 3 (1, 7)
post_p 0.35 (0.11, 0.43) 0.4 (0.14, 0.48) 0.39 (0.24, 0.48) 0.38 (0.18, 0.46) 0.36 (0.24, 0.49) 0.37 (0.2, 0.46) 0.37 (0.28, 0.47) 0.4 (0.25, 0.49)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.146 (0.113, 0.224) 0.142 (0.104, 0.402) 0.225 (0.095, 1.059) 0.174 (0.114, 0.274) 0.185 (0.104, 0.505) 0.178 (0.126, 0.436) 0.17 (0.101, 0.347) 0.174 (0.1, 0.293)
Niraparib count 26 26 26 26 26 26 26 26
time 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34) 22 (13, 34)
n 11 (5, 26) 8 (4, 21) 2 (1, 5) 4 (1, 6) 3 (1, 6) 3 (1, 5) 4 (2, 7) 3 (0, 8)
post_p 0.24 (0.09, 0.39) 0.37 (0.16, 0.47) 0.39 (0.22, 0.46) 0.34 (0.24, 0.44) 0.39 (0.2, 0.47) 0.39 (0.2, 0.47) 0.41 (0.26, 0.47) 0.39 (0.24, 0.47)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.157 (0.112, 0.336) 0.137 (0.11, 0.435) 0.224 (0.126, 0.562) 0.206 (0.116, 0.351) 0.198 (0.112, 0.369) 0.177 (0.106, 1.014) 0.154 (0.112, 0.32) 0.179 (0.093, 0.435)
DRD+ Hormone_therapies count 2 2 2 2 2 2 2 2
time 24 (21, 28) 24 (21, 28) 24 (21, 28) 24 (21, 28) 24 (21, 28) 24 (21, 28) 24 (21, 28) 24 (21, 28)
n 2 (0, 4) 0 (0, 1) 4 (3, 5) 3 (2, 4) 4 (3, 5) 4 (4, 5) 4 (3, 4) 6 (3, 10)
post_p 0.43 (0.43, 0.43) 0.41 (0.41, 0.41) 0.45 (0.43, 0.48) 0.36 (0.25, 0.47) 0.26 (0.15, 0.38) 0.36 (0.29, 0.42) 0.31 (0.29, 0.33) 0.43 (0.37, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.114 (0.114, 0.114) 0.099 (0.099, 0.099) 0.086 (0.061, 0.111) 0.169 (0.144, 0.195) 0.441 (0.333, 0.548) 0.14 (0.137, 0.142) 0.196 (0.195, 0.196) 0.16 (0.115, 0.204)
Taxel_therapies count 39 39 39 39 39 39 39 39
time 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33) 26 (18, 33)
n 7 (3, 15) 6 (2, 16) 3 (1, 5) 2 (1, 5) 5 (2, 7) 3 (1, 5) 3 (1, 5) 3 (0, 7)
post_p 0.36 (0.18, 0.47) 0.32 (0.12, 0.45) 0.35 (0.22, 0.48) 0.36 (0.23, 0.45) 0.42 (0.23, 0.48) 0.36 (0.21, 0.46) 0.36 (0.23, 0.46) 0.36 (0.17, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.134 (0.092, 0.243) 0.148 (0.093, 0.472) 0.228 (0.115, 0.816) 0.288 (0.147, 0.65) 0.161 (0.092, 0.275) 0.232 (0.131, 0.429) 0.219 (0.125, 0.816) 0.192 (0.113, 0.446)
Carboplatin count 58 58 58 58 58 58 58 58
time 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32) 20 (13, 32)
n 6 (4, 15) 6 (2, 11) 4 (1, 7) 4 (1, 7) 4 (2, 7) 3 (2, 6) 4 (1, 6) 3 (2, 5)
post_p 0.35 (0.12, 0.47) 0.33 (0.15, 0.43) 0.4 (0.24, 0.48) 0.39 (0.26, 0.48) 0.43 (0.26, 0.49) 0.4 (0.23, 0.47) 0.39 (0.2, 0.47) 0.38 (0.27, 0.47)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.135 (0.093, 0.265) 0.155 (0.1, 0.407) 0.156 (0.104, 0.447) 0.142 (0.092, 0.432) 0.16 (0.083, 0.279) 0.177 (0.109, 0.447) 0.168 (0.102, 0.44) 0.153 (0.102, 0.366)
Niraparib count 36 36 36 36 36 36 36 36
time 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31) 21 (12, 31)
n 6 (4, 14) 6 (3, 16) 3 (2, 7) 4 (1, 7) 3 (1, 8) 4 (1, 6) 4 (1, 6) 3 (1, 8)
post_p 0.3 (0.15, 0.42) 0.35 (0.14, 0.48) 0.37 (0.23, 0.49) 0.39 (0.23, 0.48) 0.36 (0.17, 0.46) 0.38 (0.26, 0.49) 0.4 (0.28, 0.48) 0.38 (0.21, 0.47)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.146 (0.091, 0.243) 0.13 (0.076, 0.286) 0.179 (0.092, 0.624) 0.183 (0.077, 0.462) 0.2 (0.1, 1.086) 0.173 (0.099, 0.485) 0.18 (0.126, 0.539) 0.178 (0.102, 0.607)
TEfus+ Hormone_therapies count 6 6 6 6 6 6 6 6
time 20 (12, 26) 20 (12, 26) 20 (12, 26) 20 (12, 26) 20 (12, 26) 20 (12, 26) 20 (12, 26) 20 (12, 26)
n 4 (1, 6) 6 (2, 10) 2 (0, 6) 2 (0, 4) 3 (3, 8) 4 (2, 6) 4 (2, 4) 4 (2, 6)
post_p 0.48 (0.42, 0.5) 0.34 (0.21, 0.44) 0.44 (0.34, 0.48) 0.39 (0.26, 0.41) 0.36 (0.19, 0.39) 0.37 (0.2, 0.47) 0.45 (0.34, 0.49) 0.42 (0.3, 0.49)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.089 (0.02, 0.11) 0.16 (0.131, 0.262) 0.13 (0.069, 0.176) 0.41 (0.14, 5.111) 0.2 (0.149, 0.493) 0.177 (0.122, 0.229) 0.173 (0.127, 0.23) 0.221 (0.081, 0.365)
Taxel_therapies count 61 61 61 61 61 61 61 61
time 21 (11, 34) 21 (11, 34) 21 (11, 34) 21 (11, 34) 21 (11, 34) 21 (11, 34) 21 (11, 34) 21 (11, 34)
n 5 (2, 11) 11 (6, 23) 4 (1, 10) 2 (0, 7) 5 (2, 10) 5 (2, 8) 2 (1, 5) 2 (0, 7)
post_p 0.3 (0.12, 0.48) 0.33 (0.17, 0.46) 0.36 (0.17, 0.48) 0.41 (0.22, 0.48) 0.39 (0.23, 0.48) 0.4 (0.24, 0.49) 0.39 (0.22, 0.48) 0.4 (0.25, 0.48)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.144 (0.084, 0.266) 0.135 (0.108, 0.231) 0.155 (0.087, 0.388) 0.199 (0.116, 0.494) 0.152 (0.108, 0.364) 0.147 (0.105, 0.253) 0.229 (0.122, 0.634) 0.2 (0.118, 0.711)
Carboplatin count 43 43 43 43 43 43 43 43
time 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33) 24 (16, 33)
n 5 (2, 8) 8 (3, 22) 6 (2, 11) 3 (2, 8) 4 (1, 7) 3 (1, 7) 3 (1, 7) 4 (1, 7)
post_p 0.31 (0.17, 0.44) 0.4 (0.19, 0.49) 0.3 (0.16, 0.47) 0.35 (0.18, 0.48) 0.34 (0.2, 0.47) 0.42 (0.23, 0.49) 0.34 (0.18, 0.48) 0.37 (0.25, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.145 (0.108, 0.273) 0.138 (0.101, 0.373) 0.128 (0.086, 0.323) 0.185 (0.107, 0.373) 0.187 (0.122, 0.476) 0.159 (0.118, 0.372) 0.207 (0.12, 0.505) 0.172 (0.104, 0.579)
Niraparib count 40 40 40 40 40 40 40 40
time 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34) 26 (15, 34)
n 5 (1, 15) 7 (3, 21) 7 (4, 18) 4 (1, 8) 5 (1, 10) 4 (2, 8) 4 (1, 7) 5 (1, 8)
post_p 0.33 (0.12, 0.47) 0.33 (0.17, 0.47) 0.27 (0.12, 0.43) 0.35 (0.2, 0.46) 0.4 (0.19, 0.49) 0.39 (0.22, 0.48) 0.38 (0.22, 0.48) 0.4 (0.26, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.13 (0.079, 0.362) 0.152 (0.12, 0.276) 0.129 (0.084, 0.212) 0.185 (0.109, 0.491) 0.177 (0.101, 0.467) 0.157 (0.108, 1.154) 0.183 (0.108, 0.451) 0.163 (0.1, 0.654)